
DMT-Harmine, Shame & Gaps in Therapist Training with Dr. Helena Aicher
What are the biggest gaps between psychedelic trials and what actually happens in the dosing room? And how might an Ayahuasca-inspired drug formulation affect shame and self-referential thinking? In this episode, we are joined by Dr. Helena Aicher, a research associate at the University of Zurich and Basel, where she is involved in clinical trials investigating psychedelic interventions. Alongside her research, she works as a psychotherapist within Switzerland’s limited medical use pathway and trains clinicians preparing to work in this field. In this conversation, we discuss her recent work on a combined DMT-harmine formulation inspired by Ayahuasca, including its effects on self-referential emotions like shame and embarrassment. Helena also shares her opinions on clinical aspects of psychedelic therapy, including the role of touch, the risks and benefits of group-based protocols, and gaps in facilitator training. More About Dr. Helena Aicher: Helena is a research associate at the Universities of Zurich and Basel, where she is involved in clinical trials investigating psychedelics. Alongside her research role, she works as a psychotherapist including the limited medical use of psychedelics in Switzerland, primarily in group settings. Bridging scientific research and frontline practice, she contributes to the development and safe implementation of psychedelic-assisted therapies. Helena is also active as a trainer in therapist training programs and serves as an advisor to several institutions.