
Key Brain Regions for Psychedelic Drug Action with Dr. Tanner Anderson
Psychedelics are often described as capable of “rewiring the brain,” but this leaves out a more complex and elegant series of mechanisms beneath the cortex. This episode goes a layer deeper to explore specific brain regions and receptors that are less often talked about in psychedelic science, despite their critical role in psychedelic drug action. Dr. Tanner Anderson, a postdoctoral neuroscientist at Yale School of Medicine, takes us on a tour through his research career so far, including his research on the claustrum (the brain's so-called "conductor" of consciousness) where he showed that the psychedelic DOI can reverse synaptic plasticity at claustrum-cortical synapses and the importance of serotonin receptors beyond 5-HT2A. We also discuss his work linking cocaine, claustrum function, and cognitive flexibility, and his current research at Yale on how MDMA affects fear circuits implicated in PTSD. Finally, Tanner helps us answer broader questions: Are psilocybin, DOI, MDMA, and ketamine converging on some shared mechanism of "reopening" plasticity in the brain, or are they doing genuinely different things in different circuits? What would it take for the field to move from compelling mechanistic stories to something clinicians can actually rely on? More About Tanner: Tanner L. Anderson, PhD, is a postdoctoral neuroscientist in the Department of Psychiatry at Yale School of Medicine. His research examines how psychedelics and entactogens alter neuronal activity and synaptic plasticity in brain circuits involved in cognition, anxiety, depression, and substance use disorders. He combines slice patch-clamp electrophysiology, Neuropixels recordings, optogenetics, viral circuit tracing, and behavioral neuroscience to study how these compounds produce both immediate and lasting changes in the brain. Tanner earned his PhD in Neuroscience from the University of Kentucky, where his research focused on psychedelic modulation of neuronal signaling and plasticity in the claustrum. Tanner is a recipient of an NIH NRSA F31 Fellowship from the National Institute on Drug Abuse and is interested in the intersection of psychedelic science, drug policy, and the development of more effective treatments for psychiatric diseases. Tanner’s Socials: linkedin.com/in/tanner-anderson-uky https://x.com/EphysTanner @tanner-anderson.bsky.social