ToxChats©

Infectious Disease Outbreaks and Disease Elimination in the 21st Century: Reflections from the 2025 ACT Plenary Speaker

In this podcast, we sit down with Dr. Yvonne Maldonado of Stanford University School of Medicine, a widely recognized leader in infectious diseases. Building on the conversation sparked by Dr. Maldonado’s plenary talk, “Infectious Disease Outbreaks...

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Weight of Evidence Approach to Carcinogenicity: An Interview with Todd Bourcier and Tim McGovern

This episode of ToxChats is designed to offer listeners a practical and insightful overview of the waiver process for carcinogenicity studies in pharmaceutical development, with a focus on the ICH S1B and S1B(R1) guidance documents. In this episode,...

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Next-Gen Toxicology: Inside the Organ Chip Revolution with Dr. Donald Ingber

In this episode of ToxChats, hosts Lauren Walker and Sarah Benjamin sit down with the groundbreaking Donald Ingber—visionary scientist, engineer, and Founding Director of the Wyss Institute. Dr. Ingber shares how his unique path through medicine,...

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Transitioning from Industry to Consulting, Independent vs. Firm Consultant

In this episode, Tanya McDonnell and Hemraj Dodiya sit down with two highly regarded toxicologists, Ric Stanulis and Mary Ellen Cosenza, who transitioned from industry and currently work as consultants, either independently or within a consulting...

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Human and Environmental Health Topic: Next Generation Risk Assessment

In this episode, Aimee Altemus and Adelaide Frimpong speak with Dr. Gary Miller of Columbia University, a widely recognized leader in exposome research. Dr. Miller discusses how the exposome—the full spectrum of environmental exposures throughout a...

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The Science of Mentorship: A Conversation with Richard DiMarchi

In this compelling ToxChats podcast episode, hosts Kristin DeSouza and Michael Dorato speak with renowned drug development scientist Richard DiMarchi as he shares his deep understanding into the art and science of mentorship within the biomedical...

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From RIF to Reboot: A Guide for Early to Mid-Career Toxicologists

Laid off—or worried you might be—and wondering what's next? In this episode, hosts Sunjay Sethi and Sarah Benjamin partner with the Early Career Professionals to demystify the post-layoff job search for early- to mid-career toxicologists. Kristin...

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Discussing the FDA's Announcement to Phase Out Animal Testing in Monoclonal Antibody Development

This podcast episode is designed to offer listeners a discussion about the FDA’s evolving stance on animal testing and exploring thoughts on its potential phase-out for monoclonal antibody (mAb) therapies. Hosted by Zac Lloyd and featuring expert...

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Specialty Tox Topic: In Vivo Dermal Drug Development

In this episode, host Zac Lloyd engages with expert in the field Colleen Johnson to discuss critical considerations in designing in vivo nonclinical programs for dermal and topical products. Through this conversation we aim to enhance understanding of...

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Specialty Tox Topic: In Vitro Dermal Drug Development

In this episode, we speak with Jean-Philippe Therrien, a senior director of R&D, to discuss critical considerations in designing nonclinical programs for dermal and topical products. Through this conversation, we aim to enhance understanding of...

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Occupational Toxicology and Product Quality: Navigating Impurities and Occupational Safety

In this episode, Dr. Katie Sokolowski and Dr. Tanya McDonnell sit down with Dr. Jessica Graham, a leader in the fields of occupational toxicology and product quality. During our time together, we discuss the current science of safety assessment,...

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The Past, Present, and Future of Safety Pharmacology

In this podcast, Dr. Derek Leishman discusses the development of regulatory guidance (ICH and GLP) for safety pharmacology studies. He follows this discussion with a conversation about nonclinical data predicting clinical outcomes, as well as...

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Career Path: Toxicologist in the Food Industry

This podcast is part of a series on the different career paths in the field of toxicology. In this episode, we interview Dr. Alex Eapen on his career path to his current position as the Director of R&D Scientific & Regulatory Affairs – North...

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Changing Approaches to Getting Drug Candidates into First-in-Human Clinical Trials: A Case Study

Not every drug that has reached human clinical trials has needed preliminary nonclinical studies to demonstrate safety. This podcast episode is a case study for replacing the use of animals during the safety testing that occurs prior to human clinical...

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Career Path: Pharmaceutical Consultant in the Field of Toxicology

This ToxChats© episode is part of a series on the different career paths in the field of toxicology. In this episode, we interview Dr. Marcus Delatte on his career path to his current position as the Vice President of Regulatory Strategy at the...

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3D Printing Emissions and Potential Health Effects from a Consumer Perspective

In this podcast, recent findings from toxicological studies on the emissions produced during fused filament fabrication (FFF) 3D printing are discussed. The use of low-cost FFF 3D printers is on the rise in households, businesses, and educational...

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Career Path: Pharmaceutical Consultant in the Field of Occupational, Environmental, and Quality Toxicology

This podcast is part of a series on different career paths in the field of toxicology. In this episode, Dr. Chuck Schwartz, PhD, DABT, shares the career path that led to his current position as the principal consulting toxicologist and managing member...

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Discussions on Identifying Seizures Liability in Nonclinical Studies

Drug-induced seizures are a major concern for central nervous system active pharmaceuticals during development. Currently, there are no guidelines for interrogating and mitigating seizure liability associated with new pharmaceuticals. Because of the...

Alternative and Nontraditional Species Series: The Use of Transgenic and Disease Mouse Animal Models for Toxicology Studies

In this ToxChats© podcast, we spoke with Dr. René Meisner, Head of Safety Assessment at Denali Therapeutics, on using both transgenic and disease mouse models in a drug development program. Topics include considerations for program design, regulatory...

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Identifying an Appropriate Sponsor to Support Your Growth and Success in the Workplace

Mentors meet with you, listen to you, and provide advice. Sponsors have influence, connections, and can speak to your talents, abilities, and potential in new opportunities. Learning how to distinguish between the two and identify a sponsor that can...

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