ScienceLife SciencesNatural Sciences

Tiny Matters

Multitude

Science shapes every facet of our lives, but so much of its influence is overlooked or buried in the past. Tiny Matters is an award-winning science podcast about the small science of big things. From the microbes behind deadly diseases to the molecules informing our search for extraterrestrial life, hosts and former scientists Sam Jones and Deboki Chakravarti embrace the awe and messiness of science and its significance both today and in the past, asking questions like, "how was IVF invented?," "what do glaciers tell us about Earth’s ancient past?," and "why is smallpox the only human infectious disease we’ve eradicated?"

Tiny Matters is created by the American Chemical Society, a non-profit scientific organization based in Washington, D.C., and is produced by Multitude. New episodes every Wednesday, wherever you listen to podcasts.

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Avg 27 min
English

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#119
Today · 41 min
How do you save a species?: Breakthroughs from cheetahs, red wolves, and 'spicy' toads
Cheetahs carry the genetic scars of an Ice Age bottleneck, red wolves are so rare that every egg matters, and harlequin frogs need their natural toxins restored before they can thrive in the wild again. But avoiding extinction requires far more than protecting habitat alone. In this episode, we talk with scientists at Smithsonian's National Zoo and Conservation Biology Institute to explore cutting-edge science helping these animals not just survive but thrive, including innovative reproductive technologies like ‘ovary-on-a-chip.’ Similar episodes you may enjoy: Extinction: Rethinking the dodo's demise, and could a supervolcano threaten humanity's future? What is de-extinction, really? Conservation, genetics, and lessons from 'dire wolves' See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Today · 2 min
Introducing What Could Go Right?
We'd like to recommend a podcast called What Could Go Right, from the Progress Network. It's a refreshingly different perspective on the news and issues like sustainability, geopolitics or the future of work. We hope you enjoy it as much as we do.
September 23 · 32 min
[BONUS] Milking spiders and why this scientist’s grave is covered in gifts: Tiny Show and Tell Us #56
In this episode of Tiny Show and Tell Us, we first discuss funnel-web spiders, who are among the most venomous spiders on Earth. Maybe somewhat paradoxically, their toxins are being studied to treat human disease and chronic pain. Then we talk with historian Claire Aubin about J. Willard Gibbs’ grave at Yale, where she’s a professor. Gibbs was a quiet scientific genius whose work transformed chemistry. He was also seemingly a very cool dude, and today his gravesite is decorated by students seeking good luck before exams. Check out This Guy Sucked wherever you get podcasts! We need your stories — they're what make these bonus episodes possible! Write in to tinymatters@acs.org or fill out this form with your favorite science fact or science news story for a chance to be featured. A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
#118
September 16 · 37 min
Biofilms: The sticky, slimy communities behind some of medicine's toughest infections
Biofilms are everywhere: your teeth, your kitchen sponge, and even medical implants. Scientists are uncovering how these highly organized microbial communities protect bacteria from antibiotics and the immune system, and how understanding their hidden lives could help us fight some of the scariest infections, particularly those that disproportionately impact people with cystic fibrosis. Learn more about CALM here. Check out Wow If True wherever you listen to podcasts! A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
September 9 · 23 min
[BONUS] ‘Drinking Grandma,’ digital cadavers and debunking a grave robbing myth: Tiny Show and Tell Us #55
In this episode of Tiny Show and Tell Us, we explore the fascinating history of embalming, from ancient mummies to arsenic-laced funeral practices (that weren’t all that long ago!). Then we chat about cadaver dissection, the importance of Leonardo da Vinci's anatomical drawings, and whether virtual reality could someday replace anatomy labs. Plus, what's the real story behind those creepy iron cages found above burial plots in old cemeteries? Learn more about CALM here. We need your stories — they're what make these bonus episodes possible! Write in to tinymatters@acs.org or fill out this form with your favorite science fact or science news story for a chance to be featured. A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
September 3 · 1 hr 6 min
The Shroud of Turin: American Medieval x Tiny Matters crossover episode
In this special bonus episode, we join American Medieval with host Matthew Gabriele, a professor of medieval studies and who knows about a LOT of history that we don’t. We're there to chat with Matt about some new science research surrounding the Turin Shroud — a cloth that many Christians believe was used to wrap Jesus after he was killed. The debates over this artifact are fascinating and the science only adds to it! So if you like science, history, and a little controversy, you’re going to love this episode. American Medieval is a podcast about the Middle Ages, but with an American twist. Each week, Professor Matthew Gabriele is joined by expert guests to explore either some fascinating part of the medieval world, or some way Americans have used this period to help them understand themselves. Matthew Gabriele is a professor of Medieval History and an elected Fellow of the Royal Historical Society (UK). In addition to hosting the podcast "American Medieval," he’s the co-author of the books The Bright Ages: A New History of Medieval Europe (Harper Books, 2021), and Oathbreakers: The War of Brothers that Shattered an Empire and Made Medieval Europe (Harper Books, 2024). His new book, Violence: A Christian History, will be out with WW Norton in late 2027/ early 2028. Learn more about CALM here. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
#117
September 2 · 37 min
Foraminifera: The one-celled predators that shaped our planet (and kept the receipts)
Single-celled marine organisms called foraminifera may be microscopic, but they've had a massive impact on life on Earth. They also leave behind intricate shells that have become part of a fossil record stretching back more than 500 million years. Today, they're one of the most powerful tools scientists have for reconstructing Earth's past climates, helping us put the current (alarming) state of our warming planet into context. Learn more about CALM here. Check out Pale Blue pod here or wherever you listen to podcasts! A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
August 26 · 25 min
[BONUS] Dangerously tiny frequencies, endometriosis tests, and cookies made from ... plastic?: Tiny Show and Tell Us #54
In this episode of Tiny Show and Tell Us, we discuss new blood tests and research into blood biomarkers that could make diagnosing endometriosis faster and less invasive. Next, we unpack subsynchronous resonance, a phenomenon that can damage power infrastructure, and is gaining new attention with so many AI data centers being built across the country. Then we hear from guest Emily Schneider who shares some delicious (maybe? You be the judge!) new research where scientists have engineered yeast to convert plastic waste and agricultural leftovers into cookies. We need your stories — they're what make these bonus episodes possible! Write in to tinymatters@acs.org or fill out this form with your favorite science fact or science news story for a chance to be featured. A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
#116
August 19 · 36 min
Giant viruses: How these amoeba-infecting behemoths are rewriting the rules of virology
Scientists spent decades searching for viruses by filtering out anything too large to be one. That strategy seemed to work well... until it didn't. When researchers discovered a microbe living inside an amoeba that looked like a bacterium but behaved like something else entirely, they uncovered a hidden world of giant viruses with massive genomes, unusual genes, and even their own viral parasites. In this episode, we dive into the discoveries that forced scientists to rethink what viruses are, how they evolve, and whether the rules historically used to define them still hold up. Check out Dreaming Against the Machine here or wherever you listen to podcasts! A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
August 12 · 30 min
[BONUS] Fairy tale evolution and the 400(ish) year old elusive Greenland shark: Tiny Show and Tell Us #53
In this episode of Tiny Show and Tell Us, we explore how scientists are using evolutionary methods to reconstruct the history of folktales like Little Red Riding Hood, Beauty and the Beast, and Jack and the Beanstalk. Then guest Matt Gabriele, professor of medieval studies and host of the podcast American Medieval, shares his fascination with Greenland sharks, leading us into the science of radiocarbon dating, longevity genetics, and the ongoing debate over whether these elusive deep-sea predators truly live for 400 years or more. We need your stories — they're what make these bonus episodes possible! Write in to tinymatters@acs.org or fill out this form with your favorite science fact or science news story for a chance to be featured. A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
#115
August 5 · 35 min
From cow’s milk to blood banks: The surprising evolution of blood transfusions
Before modern blood transfusions, doctors tried some odd alternatives, including cow's milk. In this episode, we trace the fascinating history of blood transfusions, from risky animal experiments and failed milk injections to the discovery of blood types and disease screening. You'll hear how blood transfusions became one of medicine's safest procedures, why researchers are still debating exactly when patients need them, and what innovations could make blood easier to store, transport, and use in emergency situations including the military battlefield. Check out Dreaming Against the Machine here or wherever you listen to podcasts! A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
July 29 · 18 min
[BONUS] Bread clip taxonomy and power poles on fire: Tiny Show and Tell Us #52
In this episode of Tiny Show and Tell Us, we dive into the surprisingly elaborate world of occlupanids: the humble plastic bread bag clips that have inspired an entire taxonomy complete with Latin names, species classifications, and a community of collectors. Then, we investigate a strange power outage in central Texas, where power poles caught fire after a light drizzle. We unpack the science behind pole-top fires, the "Goldilocks" weather conditions that fuel them, and the surprising technologies being used to inspect and maintain power grids across the world. We need your stories — they're what make these bonus episodes possible! Write in to tinymatters@acs.org *or fill out this form* with your favorite science fact or science news story for a chance to be featured. A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
July 29 · 2 min
Introducing What Could Go Right?
We'd like to recommend a podcast called What Could Go Right, from the Progress Network. It's a refreshingly different perspective on the news and issues like sustainability, geopolitics or the future of work. We hope you enjoy it as much as we do.
July 29 · 2 min
Introducing What Could Go Right?
We'd like to recommend a podcast called What Could Go Right, from the Progress Network. It's a refreshingly different perspective on the news and issues like sustainability, geopolitics or the future of work. We hope you enjoy it as much as we do.
July 29 · 2 min
Introducing What It's Like To Be... with Dan Heath
If you’ve ever met someone with an interesting job and wished you could ask them a hundred questions about what they really do all day, you have to check out this show. What It’s Like to Be is a podcast hosted by bestselling author Dan Heath that explores the world of work one profession at a time. We think you'll love it!
#114
July 22 · 37 min
Placebo: Why ‘fake’ treatments can have real power
A sugar pill shouldn't work as well as a real drug ... except sometimes it does. In this episode, we explore the fascinating science of the placebo effect and how expectations can shape biological outcomes. From open-label placebos and AI healthcare chatbots to the nocebo effect, we unpack what scientists know, what they still don't understand, and why the placebo response is still largely mysterious. Check out Spirits here or wherever you listen to podcasts! A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
July 15 · 23 min
[BONUS] A pathology lab, a sausage duel, and the fascinating lives of yeast: Tiny Show and Tell Us #51
In this episode of Tiny Matters, a listener who works in a pathology lab explains how even the ickiest specimens become ho-hum with time, sending Sam and Deboki down a rabbit hole of pathology history and the bizarre life of Rudolf Virchow, the “father of pathology” who was also rumored to have brought worm-filled sausages to a duel. Then, a listener's sourdough experiments spark a conversation about yeast and how these microscopic organisms are the chemists behind tasty bread, beer, wine, and more. We need your stories — they're what make these bonus episodes possible! Write in to tinymatters@acs.org *or fill out this form* with your favorite science fact or science news story for a chance to be featured. A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
#113
July 8 · 30 min
Fireworks over millennia: From battlefields and royal displays to sustainable spectacles
In medieval Europe, people who worked with early cannons and gunpowder were viewed as untrustworthy, boorish outsiders. But just a few centuries later, as they began creating elaborate fireworks displays for royalty, they went from outcasts to artists. From black powder to modern low-smoke pyrotechnics, in this episode of Tiny Matters we look at the chemistry, engineering, and artistry behind one of humanity's favorite forms of celebration. We also learn how scientists are reinventing pyrotechnics with cleaner-burning compounds that deliver brighter colors and fewer emissions. And check out this video from our friends at Headline Science to get a behind the scenes tour of the Science History Institute’s new exhibit: Flash! Bang! Boom! A History of Fireworks. Check out Simple and Clean here or wherever you listen to podcasts! A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
July 1 · 16 min
[BONUS] The ‘elite neutralizers’ immune to HIV and why galaxies ‘FART’: Tiny Show and Tell Us #50
This week on Tiny Show and Tell Us, a listener introduces us to "FARTs" — a silly acronym for galactic gas outflows — and sends us down a rabbit hole of dying stars and recycled cosmic gas in the early universe. Then we discuss the decades-long search for broadly neutralizing antibodies (bNAbs) that can target many HIV strains at once. One bNAb that looks promising is in clinical trials right now! We need your stories — they're what make these bonus episodes possible! Write in to tinymatters@acs.org *or fill out this form* with your favorite science fact or science news story for a chance to be featured. A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
#112
June 24 · 36 min
Collisions in space: Satellites, space debris, and the quest to clean up Earth's orbit
We tend to think of space as vast and mostly empty, yet the region just above Earth is far from it. In this episode, we explore the surprising congestion of low Earth orbit, where tens of thousands of satellites and millions of pieces of debris are hurtling around at incredible speeds. From a major satellite collision in 2009 to the looming threat of the Kessler Effect — where Earth’s orbit becomes so densely packed that collisions set off an unstoppable chain reaction — we unpack how even tiny fragments can cause massive damage to spacecraft, disrupt critical services, and potentially put astronauts and even us Earth dwellers at risk. We talk with scientists about creative solutions that could help tackle this growing problem, including space lasers, and we ask an important question: who is responsible for keeping space clean? Check out American Medieval here or wherever you listen to podcasts! A transcript and references for this episode can be found at acs.org/tinymatters. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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