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MDS Podcast

International Parkinson and Movement Disorder Society

Stay up to date on novel, clinically-relevant research findings in Parkinson's disease and other movement disorders. Each episode of the International Parkinson and Movement Disorder Society podcast discusses a relevant development in the field, including highlighted journal articles and interviews with the authors.

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  • 27 episodes
  • weekly
  • English

Episodes 27

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  • September 23 · length unknown

    Junior Awardee: Can cortical signals tell us what is happening in the deep brain? | Congress 2026

    In this episode, we speak with Zixiao Yin, recipient of a Junior Award at the MDS Congress, about his work on reconstructing deep brain activity from cortical signals. Using more than 700 hours of simultaneous cortical and subcortical recordings across different movement disorders, brain targets, and clinical states, Yin and colleagues developed deep learning approaches to infer subcortical activity from cortical recordings. We discuss why this could matter for adaptive DBS, how cortical signals can be used to estimate STN beta activity and reconstruct deep brain signals, and whether this approach could provide an alternative when direct subcortical sensing is unreliable.

  • September 14 · length unknown

    Setting the TEMPO: What have we learned about D1/D5 dopamine stimulation in Parkinson’s disease?

    Dr. Divyani Garg speaks with Dr. Hubert H. Fernandez about tavapadon, a once-daily selective dopamine D1/D5 receptor agonist, and what the TEMPO clinical development program tells us about its potential role in Parkinson’s disease (PD). They discuss the rationale for D1/D5 stimulation, findings from other TEMPO programs, the magnitude and clinical meaning of the motor benefit, flexible dosing, and the important tolerability and discontinuation findings from TEMPO-2. The conversation also explores where tavapadon might fit relative to levodopa and conventional D2/D3 dopamine agonists, and its potential role across different stages of PD. Read the article.

  • September 8 · length unknown

    History of Movement Disorders: Animal models for studying Parkinson's disease

    Prof. Jeffrey Kordower and Prof. Franziska Richter Assêncio join Prof. Tiago Outeiro to discuss the historical use of animal models in the field of Parkinson's disease. Together they review ethical issues, the value of different types of models, and their relevance to the field.

  • August 31 · length unknown

    Hot Topic: Prodromal Parkinson's disease

    In this new episode of the Hot Topic 'Prodromal synucleinopathies' Dr. Eva Schäffer joins Dr. Eduardo de Pablo Fernández to discuss recent advances, future challenges, and practical clinical advice in prodromal Parkinson's disease.

  • August 24 · length unknown

    What is it? A young girl with subacute jerky movements

    In this episode, Dr. Kathryn Yang discusses a case of a young girl with subacute-onset jerky movements with an interesting finding on oculomotor examination, and explores the etiological diagnosis of this peculiar syndrome. Read the article.

  • August 3 · length unknown

    ERNA: A newer neurophysiological biomarker to automate DBS programming

    In this episode, Dr. Mitra Afshari speaks with Dr. Jen Nagao about her latest work highlighting the automation of subthalamic deep brain stimulation (DBS) with Evoked Resonant Neural Activity (ERNA) in Parkinson’s disease. They discuss the potential benefits of ERNA over beta power in the operating room and future opportunities to explore this newer neurophysiological marker for DBS programming. Read the article. Journal CME is available until June 30, 2027.

  • July 27 · length unknown

    DaxibotulinumtoxinA for cervical dystonia

    Dr. Todd Gross and Dr. Laxman Bahroo discuss with Dr. Sara Schaefer the real-world use of daxibotulinumtoxinA in patients with cervical dystonia following initial clinical trials and FDA approval. Read the article.

  • July 20 · length unknown

    What is it? Recurrent behavioral arrest and loss of postural reflexes

    Dr. Asif Doja explores the diagnostic possibilities of behavioral arrests and loss of postural reflexes in a young boy, and details the diagnostic approach to such cases. View the case videos: KCNMA1-Related Episodes of Behavioral Arrest and Loss of Postural Reflexes Cataplexy in Patients Harboring the KCNMA1 p.N999S Mutation

  • July 13 · length unknown

    Hot Topic: Music therapy in the rehabilitation of persons with Parkinson's disease

    Ms. Nicole Duff spends time with Mrs. Cassandra Mulcahy and Prof. Stefan Mainka, both of whom are qualified music therapists. They discuss the benefits of music therapy in treating both motor and non-motor symptoms in persons with Parkinson's disease. Different forms of music therapy are discussed, along with the physiology behind them. Lastly, possible future directions of music therapy in the rehabilitation of persons with Parkinson's disease were explored.

  • July 6 · length unknown

    Beyond the gene: Targeting neuroinflammation in Huntington's disease

    Dr. Sarah Camargos is joined by Dr. Rajeev Kumar to explore early research on targeting neuroinflammation in Huntington's disease. Dr. Kumar delves into the intricacies of the complement cascade, highlighting the pivotal role of C1q as the recognition molecule at the top of this immune system chain reaction and how ANX005 aims to prevent the initiation of the cascade. He further discusses the implications of biomarker advancements and safety protocols in moving towards more effective treatments for Huntington's disease. Read the article. Journal CME is available until June 30, 2027.

  • June 29 · length unknown

    Hot Topic: Argentine tango in the rehabilitation of persons with Parkinson's disease

    Ms. Nicole Duff and Prof. Hae-Young Hawong discuss the benefits of Argentine tango in the rehabilitation of person's with Parkinson disease. The motor, non-motor, social, and quality of life gains are all explored; in addition to, the neuro-anatomical, neurophysiological and neuroplastic benefits. Prof. Hawong also describes the very successful and passion-based Argentine tango program she has established at the Yale School of Medicine.

  • June 22 · length unknown

    Blocking alpha-synuclein propagation with perampanel

    Dr. Norihito Uemura joins Prof. Tiago Outeiro to discuss perampanel, an AMPA receptor antagonist, and how it has been shown to block alpha-synuclein propagation and neurodegeneration in a mouse model of Lewy body disease. Dr. Uemura explains the mechanistic findings of transsynaptic propagation and the study limitations pertaining to mouse behavior. They also discuss perampanel’s established therapeutic ranges in epilepsy, review limited prior Parkinson’s data, and outline next steps including a potential clinical trial in Parkinson’s disease patients. Read article. Journal CME is available until June 5, 2027.

  • June 15 · length unknown

    End of life preferences of people with Parkinson's disease

    Ms. Nicole Duff and Dr. Marjan Meinders discuss end of life preferences of people with Parkinson’s disease. Together they discuss the ways that end-of-life records could be sourced, as well as what information could be found in the end-of-life record. They further dive into the differences between specific European countries and the reasons around the low rate of end-of-life records for people with Parkinson's disease.

  • June 8 · length unknown

    Quality of life in Parkinson’s disease

    Dr. Connie Marras discusses with Dr. Sara Schaefer her recent study in Movement Disorders Clinical Practice exploring the perspective of Persons with Parkinson's disease on the definition of quality of life. Read the article.

  • June 1 · length unknown

    New data to reframe the risks of DBS surgery for patients and providers

    Myths and misconceptions related to the surgical risks of deep brain stimulation (DBS) procedures remain common despite many years of evidence demonstrating its relative safety. This leads to both patient and provider fear in referring eligible patients for consideration of a potentially life-altering therapy for symptom management in many movement disorders. Dr. Mitra Afshari speaks to functional neurosurgeon, Dr. Chengyuan Wu, about a recent large retrospective study he conducted comparing risks of DBS surgery to other common elective surgeries. They also bring in the perspective of DBS specialist, Dr. Delaram Safarpour, who recently published expert consensus recommendations for referral of Parkinson’s disease patients for DBS. Listen in on the lively discussion of how we can reframe this conversation with our patients and colleagues. Read the retrospective study. Read the expert consensus recommendations.

  • May 26 · length unknown

    Ataxia Series: Treating cerebellar ataxia in 2026 - What's new?

    For many years ataxias, especially the genetic forms, were considered untreatable diseases. In this episode Dr. Orlando Barsottini and Dr. Liana Rosenthal discuss the new advances in the treatment of ataxias and perspectives for the future.

  • May 18 · length unknown

    Prodromal autonomic dysfunction in Lewy body diseases

    Prodromal autonomic dysfunction has emerged as an important area of research in understanding Lewy body diseases, including Parkinson's disease, and dementia with Lewy bodies. Dr. Michelle Matarazzo sits down with three experts in the field, Dr. Abhimanyu Mahajan, Dr. Alison Yarnall, and Dr. David Goldstein to discuss the current evidence behind various disturbances and how they may precede classic motor and cognitive symptoms, such as cardiovascular, gastrointestinal, urinary, and thermoregulatory disturbances. Together they discuss how these early non-motor manifestations may be considered integral features of the disease process. Read the related Scientific Issue Discussion on this topic.

Showing 1–20 of 27 episodes