
E224: Constance Fourny - Brain Cancer Immunology and Life as a PhD Researcher
Trigger Warning: this episode discusses brain cancer and the use of patient blood and tumour samples in research. Episode 224: Part of the Education and Workforce Development series (Part 76) Description: In this fascinating episode, Naman Julka-Anderson and Jo McNamara sit down with Constance Fourny. Connie is a final-year PhD student whose career has taken her into the world of cancer research. Her work explores proteins, peptides, cell signalling and how cells move, focusing on gliomas and identifying targets for new brain cancer treatments by studying how the immune system responds to peptides presented on the surface of tumour cells. Having grown up in France before moving to the UK, Connie studied biomedical science, fell in love with immunology, and completed her master's in immunology at King's College London before starting her PhD. She hopes to continue in academic cancer research after her viva. This episode is a deep dive into how cancers evade the immune system, why gliomas are so difficult to treat, how patient consent works for research samples, and the resilience, optimism and sense of purpose behind laboratory cancer research. CPD Reflection Points: 1. Understanding tumour biology: Connie described how gliomas vary between patients and within a single tumour, and how cancers can evade immune detection. How does understanding the biology behind treatment resistance shape the way you would explain treatment options, outcomes or emerging therapies such as immunotherapy and CAR-T cell therapy to patients? 2. The person behind the sample: Connie spoke about informed consent for tissue samples and staying connected to the patient behind each one. How is consent for research handled in your setting, and how do you keep the patient at the centre when you work with their data, images or treatment plans rather than with them directly? 3. Contributing to research: Connie compared research to laying the foundation stones of a cathedral. What role do you and your team currently play in research, and what one step could you take to engage with it more, whether through recruitment, patient and public involvement, or connecting with laboratory scientists? Complete this form for your accredited digital badge: Digital Badge Form. Links from the Episode: Radiation Reveal Cancer Research UK RadNet Brain Tumour Research Francis Crick Institute Research links from the Episode: OPN-Derived Peptides Generated by Proteasomes Can Promote Cell Migration via CD44 Activation Stable β2-Microglobulin–HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer-Associated Epitopes Challenges in glioblastoma immunotherapy: mechanisms of resistance and therapeutic approaches to overcome them Next-generation antigen-presenting cell immune therapeutics for gliomas Overcoming immunotherapy resistance in glioblastoma: challenges and emerging strategies Guiding principles and the fundamental principle of consent: guide for the general public Radiation Reveal: Moving from research engagement to involvement Plea for brain tumour research funding as PM to meet with Archie Goodburn Rad Chat Links: Rad Chat Website Link Tree Facebook Instagram LinkedIn TikTok BlueSky YouTube Credits: Music and jingle credits: Dr. Ben Potts and Adam Cooke. © Rad Chat 2026. All rights reserved. We (or our licensors) own all intellectual property rights in this podcast and all related content, online and offline. You may not use, copy, modify, download, archive, reproduce, distribute, display, publish, licence, create derivative works from or commercially exploit any part of our content unless we expressly agree in writing. You must not use any images, audio, video, graphics or clips separately from their accompanying context. Please acknowledge Rad Chat (and any identified contributors) clearly whenever referencing or sharing our content.
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