

1 in 20 Women Have PMDD: Why Hormone Tests Come Back Normal | ADHD, Autism, Endometriosis, PMOS Connections | The Science Behind PMS and PMDD with Neuroscientist Dr Emilė Radytė
Send us Fan Mail "Every Two Weeks You Are No Longer Yourself" Dr Emilė Radytė is a Harvard and Oxford-trained neuroscientist and the co-founder and CEO of Samphire Neuroscience, where she builds neurotechnology for women's health. Her work treats PMS, PMDD and menstrual pain as conditions of the brain, not just the hormones. She was named in Forbes 30 Under 30 for healthcare in 2024. TW: We discuss depression and suicide in this epsiode. 💬 Top quotes "If you live with PMDD, it means every two weeks you are no longer yourself, so you lose literally half of all of your reproductive life." "When most women test their hormones, they find out it's perfectly fine. The reason they have those symptoms is because of how their brains respond to those hormones." "For years, depression was called hysteria in women, and so I think the idea that women could have something specific is already relatively new." "A stable job expects you to show up the same way every day, and is built for a male-like cycle, where women, we know we're not the same every day anyway." "Hormones are just the way that our bodies talk to us, and I think if anyone gets anything from this talk, that should be the key." 🧠 What we cover: Why PMDD is a recognised medical condition, not a bad mood, and how it differs from PMS even when the symptoms overlap Why most women with PMDD have completely normal hormone levels, and what that really means The two weeks before your period, explained: why the part of your brain that regulates emotion goes offline, and why that isn't a character flaw The woman who writes a resignation letter every single month, and what it tells us about impulsivity in PMDD Progesterone, allopregnanolone and GABA: why a hormone that calms most women can do the opposite for some Why your pain threshold drops during your period, so you feel more pain and have more to feel PMDD was only recognised as a depressive disorder in 2014, which means most psychiatrists trained before it existed What the evidence actually says about supplements, and whether they reach your brain at all The pill and PMDD: what it does, what it doesn't, and why options matter more than answers How brain stimulation works, whether it lasts, and what neuroplasticity really means Why ADHD and PMDD so often show up together, and what's happening in the prefrontal cortex The link between stress, your brain and the timing of your cycle Why hormones are the message, not the cause, including in PMOS (PCOS) What we still don't know about PMDD and long-term brain health ⚠️ One correction to note In the episode, Emilė says 70% of women with PMDD have ADHD or autism. The research runs the other way: studies measure how many people with ADHD or autism also experience PMDD, not the reverse. I couldn't find a figure for the share of people with PMDD who have ADHD or autism. The comorbidity itself is well documented. 💛 Support Please remember support is available any time. Samaritans 116 123 (UK, free, 24/7). Call or text 988 (US). IAPMD at iapmd.org has PMDD-specific support and free self-screening tools. This episode is for information, not medical advice, so please speak to your GP or a clinician about your own symptoms. Support the show Follow us on Instagram or TikTok, or subscribe via YouTube. We've reached 1.6 million views across all platforms, proudly covering some of the most chronic and confusing conditions and diseases that disproportionately affect women.
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