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ICU Ed and Todd-Cast

Eddie and Todd

Two critical care guys walk into a recording studio and breakdown intensive care trials both old and new! We'll also do deep dives on specific topics important to practicing intensive care medicine and have special guests talking about their area of expertise! This podcast is made for educational purposes. The content provided in this podcast, and in any linked materials, is not intended and should not be construed as medical advice and should not be used to diagnose or treat any medical condition. We try to stay away from opinions but all opinions represent our own and not of any entity we work for. Please keep this in mind as you enjoy the podcast!

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21 episodes
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English

Episodes 21

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S1 · E102
October 6 · 49 min
New/Old: RATE and CESAR
Send us a Text Message (please include your email so we can respond!) Episode 102! In this episode we talk about ECMO anticoagulation strategies with RATE and go back in time to talk about the original landmark trial for ECMO in CESAR RATE: https://pubmed.ncbi.nlm.nih.gov/42413523/ CESAR: https://pubmed.ncbi.nlm.nih.gov/19762075/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E101
September 22 · 44 min
Old/New: TTM2 and ICECAP
Send us a Text Message (please include your email so we can respond!) Episode 101! In this episode we talk about targeted temperature management starting with TTM2 to set the stage and moving towards ICECAP published by Muerer et al in JAMA August 2026! TTM2: https://pubmed.ncbi.nlm.nih.gov/34133859/ ICECAP: https://pubmed.ncbi.nlm.nih.gov/42554995/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E100
September 8 · 45 min
New: Olanzapine vs Dex and a look back
Send us a Text Message (please include your email so we can respond!) Episode 100! Can't believe we made it here. 100 episode of trying to fit into Todd's triple booked schedule. This episode we do a little reminiscing about the past 3 years of podcasting but not after talking about a trial published in the form of a research letter about olanzapine versus dexmedetomidine for delirium by Liu et al published in the Blue Journal May 2026 Olanzapine vs Dex: https://pubmed.ncbi.nlm.nih.gov/42118124/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E99
August 25 · 38 min
NEXIS and Mailbag
Send us a Text Message (please include your email so we can respond!) Episode 99! In this episode we talk about Nutrition and Exercise in Critical Illness published in AJRCCM June 2026 by Needham et al. A shorter episode today as we're dealing with end-of-summer travel schedules so we add a mailbag segment to this one. NEXIS: https://pubmed.ncbi.nlm.nih.gov/42438140/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E98
August 11 · 55 min
Old/New: EUPHRATES and Tigris
Send us a Text Message (please include your email so we can respond!) Episode 98! We talk about polymyxin B filtration of endotoxin for patients with septic shock in EUPHRATES which sets the stage for Tigris. We also butcher Mesopotamian history (sorry!) EUPHRATES: https://pubmed.ncbi.nlm.nih.gov/30304428/ Tigris:https://pubmed.ncbi.nlm.nih.gov/41887242/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E97
July 28 · 56 min
New/New: MARCH and Tele-Rehab
Send us a Text Message (please include your email so we can respond!) Episode 97! In this episode we talk about mucolytics for patients with difficult to clear secretions on the ventilator and the effects of a tele ICU rehabilitation intervention! We also have some emails following up on scurvy and the taste of chalk. Scurvy History:https://pmc.ncbi.nlm.nih.gov/articles/PMC1276007/ Bootcamp: https://www.vumc.org/advanced-practice-critical-care/welcome MARCH: https://www.nejm.org/doi/pdf/10.1056/NEJMoa2603406 Tele-Rehab: https://jamanetwork.com/journals/jama/article-abstract/2850403 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E96
July 14 · 1 hr 5 min
New/New: ARISE-FLUIDS and VICTORY (+mail)
Send us a Text Message (please include your email so we can respond!) Episode 96. In this episode we talk about ARISE FLUIDS (early pressors vs early fluids) and VICTORY (high dose Vitamin C in severe burn) both simultaneously presented and published at the CCR26 conference. Then we start digging out form our ever growing mailbag ARISE-FLUIDS: https://pubmed.ncbi.nlm.nih.gov/42274006/ VICTORY: https://pubmed.ncbi.nlm.nih.gov/42267875/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E95
June 30 · 52 min
New/New: BiHCA and SODa-BIC
Send us a Text Message (please include your email so we can respond!) Episode 95! In this episode we talk about "Sodium Bicarbonate for In-Hospital Cardiac Arrest" by Granfeldt et al and "Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock" published by the ANZICS group both presented at the CCR26 conference. BiHCA: https://pubmed.ncbi.nlm.nih.gov/42273960/ BiHCA: https://jamanetwork.com/journals/jama/article-abstract/2850405 SODa-BIC: https://pubmed.ncbi.nlm.nih.gov/42283370/ SODa-BIC: https://www.nejm.org/doi/10.1056/NEJMoa2600526 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E94
June 16 · 55 min
CCR26 and the unpublished results presentations
Send us a Text Message (please include your email so we can respond!) Episode 94! In this episode we give some general reactions to the CCR conference, discuss our impact on the critical care world, and talk briefly about 3 of the presentations from the conference that did NOT have a simultaneous publication (REMAP-CAP oseltamivir, FISSH, and SAVE-ICU) If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E93
June 2 · 1 hr 2 min
NEW: ATS 2026 and Hantavirus?
Send us a Text Message (please include your email so we can respond!) Episode 93! In this episode we go over TOWAR or "Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage" by Sperry et all published in NEJM and "Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors" published by O'Neill et al in JAMA both in May 2026 and presented at the ATS International Conference! Then we talk a little bit about some current events with Hantavirus and sepsis that has hit the news cycles TOWAR (NEJM): https://www.nejm.org/doi/full/10.1056/NEJMoa2602167 iRehab (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2849320 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E92
May 19 · 41 min
New: R2D2
Send us a Text Message (please include your email so we can respond!) Episode 92! In this episode we talk about "Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients" published in JAMA by Sonneville et al April 2026! R2D2 (pubmed): https://pubmed.ncbi.nlm.nih.gov/41841304/ R2D2 (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2846726 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E91
May 5 · 44 min
New: 4D
Send us a Text Message (please include your email so we can respond!) Episode 91! In this episode we talk about "Dexmedetomidine for treatment of hyperactive delirium in non-intubated ICU patients" published by Godet et al in Intensive Care Medicine October of 2025! We are going to be on a one article per episode kick for a while but hope to get back to normal programming soon! 4D: https://pubmed.ncbi.nlm.nih.gov/41160116/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E90
April 21 · 1 hr 2 min
New: 2026 Sepsis Guidelines
Send us a Text Message (please include your email so we can respond!) Episode 90! In this episode we talk about the 2026 Surviving Sepsis Campaign Guidelines lead by Prescott et all and published in Critical Care Medicine in March of 2026! We review all that's new and all that's changed If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E89
April 7 · 48 min
New: Hi-PEITHO
Send us a Text Message (please include your email so we can respond!) Episode 89! In this episode we talk about HI-PEITHO or catheter directed thrombolysis versus conventional anticoagulation for intermediate risk pulmonary embolism. This was published in the New England Journal of Medicine by Rosenfield et al. HI-PEITHO: http://nejm.org/doi/full/10.1056/NEJMoa2516567 HI-PEITHO (pubmed): https://pubmed.ncbi.nlm.nih.gov/41910345/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E88
March 24 · 46 min
New/New: PE and CPR Guidelines
Send us a Text Message (please include your email so we can respond!) Episodes 88! In this episode we talk about guidelines recently released for the management of pulmonary embolism and cardiac arrest! A little hap hazard of an episode as we jump around from topic to topic but good to highlight things that are new and things that are changing! PE: https://pubmed.ncbi.nlm.nih.gov/41712898/ CPR: https://pubmed.ncbi.nlm.nih.gov/41122893/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E87
March 10 · 47 min
Old/New: ALBIOS and ARISS
Send us a Text Message (please include your email so we can respond!) Episode 87! In this episode we talk about Albumin with two related studies, ALBIOS ("Albumin replacement in patients with severe sepsis or septic shock" by Caironi et al) and ARISS ("Albumin Replacement Therapy in Septic Shock" by Sakr et al) ALBIOS: https://pubmed.ncbi.nlm.nih.gov/24635772/ ARISS: https://pubmed.ncbi.nlm.nih.gov/41712212/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E86
February 24 · 47 min
New: PreVent2
Send us a Text Message (please include your email so we can respond!) Episode 86! In this episode we talk about endotracheal tubes or "Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation" published in Lancet Respiratory Medicine February 2026 by Treggiari et al. Pubmed: https://pubmed.ncbi.nlm.nih.gov/41319662/ LRM: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00294-2/abstract If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E85
February 10 · 58 min
New: LIBERATE-D with Eddie Siew
Send us a Text Message (please include your email so we can respond!) Episode 85! In this episode we go over LIBERATE-D or "A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury" by Liu et al in JAMA 2026. We have the second author, Eddie Siew, on with us to discuss! LIBERATE-D (pubmed): https://pubmed.ncbi.nlm.nih.gov/41201895/ LIBERATE-D (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2841171 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E84
January 27 · 36 min
CCR Down Under: ACTiVE and CLIP2
Send us a Text Message (please include your email so we can respond!) Episode 84! In this episode we finish up our discussion of the articles presented with the CCR Down Under Conference with ACTiVE (close loop ventilation) and CLIP2 (cryopreserved platelets for surgical bleeding). Both are neutral trials at best, so we took them both pretty short. ACTiVE: https://pubmed.ncbi.nlm.nih.gov/41361939/ ACTiVE (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2842610 CLIP2: https://pubmed.ncbi.nlm.nih.gov/41360717/ CLIP2 (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2842479 If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
S1 · E83
January 13 · 46 min
CCR Down Under: ImmunoSep
Send us a Text Message (please include your email so we can respond!) Episode 83! Only one article this episode since Todd is feeling a little under the weather, but still a good discussion! ImmunoSep (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2842634 ImmunoSep (pubmed): https://pubmed.ncbi.nlm.nih.gov/41359996/ If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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