Campbellteaching
Hello Everyone, My name is John Campbell and I am a retired Nurse Teacher and former clinical nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally. LinkedIn profile, https://www.linkedin.com/in/dr-john-campbell-5256223b/ Twitter, https://twitter.com/Johnincarlisle Disclaimer; These media including videos, book, e book, articles, podcasts are not peer-reviewed. They should never replace individual clinical judgement from your own health care provider. No media-based material on this channel is suitable for using as professional medical advice. All comments are also for educational purposed only and must never replace advice from your own health care provider
Thanks to Rebecca at DW News. Omicron cases will rise in Europe over the next few weeks. This will mean tens of millions of people will have the infection all at the same time. However, South Africa has had this variant for a month, and hospital admissions remain low. Learn more about your ad choices. Visit megaphone.fm/adchoices
Dr. Aseem Malhotra, direct link to expert testimony in Finland https://casecovidpass.com/wp-content/uploads/2024/04/Dr-Aseem-Malhotra-testimony-before-Helsinki-District-Court-12-April-2024-in-Finland-MPXjVFzs8dE.mp3 Learn more about your ad choices. Visit megaphone.fm/adchoices
Full version of this talk with Professor Robert Clancy, doctor, immunologist, consultant physician, professor of pathology and professor of medicine, highly published medical researcher, author, teacher, doctor of science, doctor of philosophy, holder of the Australia Medal. Link to buy the book, https://covidthroughoureyes.com.au/products/covid-through-our-eyes-an-australian-story-of-mistakes-mistreatment-and-misinformation Learn more about your ad choices. Visit megaphone.fm/adchoices
58% of covid US deaths now in the vaccinated Kaiser Family Foundation vice president Cynthia Cox https://www.cdc.gov/vaccines/covid-19/effectiveness-research/protocols.html https://covid.cdc.gov/covid-data-tracker/#rates-by-vaccine-status https://www.cdc.gov/coronavirus/2019-ncov/vaccines/effectiveness/monitoring.html https://data.cdc.gov/Public-Health-Surveillance/Rates-of-COVID-19-Cases-or-Deaths-by-Age-Group-and/d6p8-wqjm https://www.washingtonpost.com/politics/2022/11/23/vaccinated-people-now-make-up-majority-covid-deaths/ 58% of coronavirus deaths in August were people who were vaccinated or boosted (people who had completed at least their primary series of vaccines) Therefore 42% coronavirus deaths in August were people who were unvaccinated First time there were more deaths covid deaths in the vaccinated versus the unvaccinated https://covid.cdc.gov/covid-data-tracker/#vaccinations_vacc-people-booster-percent-pop5 In September 2021 Vaccinated people, 23% of coronavirus fatalities In January and February 2022 Vaccinated people, 42% of coronavirus fatalities We can no longer say this is a pandemic of the unvaccinated (who conducted the analysis on behalf of the Post) https://www.cdc.gov/mmwr/volumes/71/wr/mm7144a3.htm?s_cid=mm7144a3_w Safety Monitoring of Bivalent COVID-19 mRNA Vaccine Booster Doses Among Persons Aged ≥12 Years — United States, August 31–October 23, 2022 On August 31, 2022 FDA authorized bivalent, Pfizer-BioNTech and Moderna mRNA encoding the spike protein from original strain of SARS-CoV-2, and from Omicron BA.4 and BA.5 Advisory Committee on Immunization Practices (ACIP) recommended, all persons ≥12 years receive an age-appropriate bivalent mRNA booster dose v-safe a voluntary smartphone-based U.S. safety surveillance system, established by CDC to monitor adverse events after COVID-19 vaccination As of 3rd October, 10 million users https://icandecide.org/press-release/breaking-news-ican-obtains-cdc-v-safe-data/ Vaccine Adverse Event Reporting System (VAERS) Total data, August 31–October 23, 2022 14.4 million received a bivalent Pfizer-BioNTech 8.2 million adults (≥18 years) a bivalent Moderna booster dose v-safe, among the 211,959 registrants (aged ≥12 years) August 31–October 23, 2022 Reported in the week after vaccination Injection site reactions, 60.8% Systemic reactions, 54.8% Fewer than 1% of v-safe registrants reported receiving medical care Vaccine Adverse Event Reporting System (VAERS) 5,542 reports of adverse events after bivalent booster vaccination (≥12 years) 95.5% of reports were nonserious 4.5% were serious events Health care providers and patients can be reassured that adverse events reported after a bivalent booster dose are consistent with those reported after monovalent doses. Relative risk Absolute risk not given Health impacts after COVID-19 vaccination are less frequent and less severe than those associated with COVID-19 illness (2). Relative risk Absolute risk not given This is their Reference 2 Block JP, Boehmer TK, Forrest CB, et al. Cardiac complications after SARS-CoV-2 infection and mRNA COVID-19 vaccination—PCORnet, United States, January 2021–January 2022. MMWR Morb Mortal Wkly Rep 2022;71:517–23. https://doi.org/10.15585/mmwr.mm7114e1 PMID:35389977 myocarditis; myocarditis or pericarditis; and myocarditis, pericarditis, or MIS, within 7-day or 21-day risk windows after the index date Comparisons between after vaccine and after infection Relative risk Absolute risk not given Review of v-safe Data During August 31–October 23, 2022 211,959 v-safe registrants had a bivalent booster 1,464 (0.7%) were aged 12–17 years 68,592 (32.4%) were aged 18–49 years 59,209 (27.9%) were aged 50–64 years 82.694 (39.0%) were aged ≥65 years Fourth dose 96,241; 45.4% Fifth dose 106,423; 50.2% In the week after receipt of the biva Learn more about your ad choices. Visit megaphone.fm/adchoices
Idaho, activates “crisis standards of care” https://www.washingtonpost.com/nation/2021/09/07/covid-delta-variant-live-updates/ Activated “crisis standards of care” 10 hospitals because of a severe shortage of staffing and available beds massive increase in patients with COVID-19 who require hospitalization Less than 40% fully vaccinated May have to wait for beds Get treated in hallways etc Delayed operations Basic equipment may not be available Governor Brad Little More Idahoans need to choose to receive the vaccine so we can minimize the spread of the disease and reduce the number of COVID-19 hospitalizations, many of which involve younger Idahoans and are preventable with safe and effective vaccines United States data https://covid.cdc.gov/covid-data-tracker/#trends_dailytrendscases https://covid.cdc.gov/covid-data-tracker/#vaccination-trends https://covid.cdc.gov/covid-data-tracker/#hospitalizations UK data https://coronavirus.data.gov.uk Australian data https://www.health.gov.au/news/health-alerts/novel-coronavirus-2019-ncov-health-alert/coronavirus-covid-19-case-numbers-and-statistics Cuba https://www.washingtonpost.com/world/2021/09/06/brazil-coronavirus-vaccine-vaccination-rollout-sinovac/ Vaccinating from 2 years Own vaccine, Soberana 02 Cuba’s Finlay Vaccine Institute https://www.cecmed.cu/noticias/aprueba-cecmed-autorizacion-uso-emergencia-vacuna-cubana-soberanar-02-poblacion-pediatrica 3 to 18 years similar trial efficacy as 19 to 29 The safety profile evidenced was similar between the groups compared Adults in Cuba Abdala vaccine, (efficacy, 92%) since July Neither vaccines recognized by WHO (Chile’s health authority, approved Sinovac 6 year olds) Afghanistan About 90% of 2,300 medical facilities at risk of closure International humanitarian donors struggle to operate The Leading Causes of Death in the US for 2020 https://jamanetwork.com/journals/jama/fullarticle/2778234 National Center for Health Statistics (NCHS) National Vital Statistics System (NVSS) https://www.cdc.gov/nchs/nvss/manuals/2a-2021.htm Data from 50 states and the District of Columbia Increase number of deaths between 2019 and 2020, 15.9 to 17.7% https://www.cdc.gov/mmwr/volumes/70/wr/mm7014e1.htm?s_cid=mm7014e1_w Increases in many leading causes of death Code, International Statistical Classification of Diseases and Related Health Problems, Tenth Revision https://icd.who.int/browse10/Content/statichtml/ICD10Volume2_en_2010.pdf Based on the underlying cause of death The disease or condition responsible for initiating the chain of events leading to death Total deaths, 2,712,630 Heart disease, 633,842 Cancer, 595,930 Covid-19, 345,232 (647,461 now) Unintentional injuries, (ODs) 192,176 Stroke, 159,050 COPD, 151,637 Alzheimer’s, 133,382 Diabetes, 101,106 Influenza and pneumonia, 53,495 Kidney disease, 52,260 Suicide, 44,834 Direct and indirect effects of the pandemic Most increase in deaths, directly attributed to COVID-19 Underreporting of COVID-19 Increases heart disease, Alzheimer, diabetes Disruptions in early detection and disease management Increases in unintentional injury largely driven by drug overdose Life expectancy at birth, largest decline since 1943 Do you support vaccine mandates? Please vote here, https://www.youtube.com/c/Campbellteaching/community Learn more about your ad choices. Visit megaphone.fm/adchoices
Chinese and Western vaccines compared https://www.bbc.co.uk/news/world-asia-china-63855508 Big changes, all of a sudden Live with the virus Vice-premier, Sun Chunlan China entering a new situation Virus ability to cause disease weakening Lifting most severe Covid policies End of quarantine camps People can isolate at home No more family separations Close contacts not taken to camps Strict ban on blocking fire exits No need to show tests for venues Less rules on internal travel Lateral flow tests to replace PCR tests in most areas Lockdowns continue in smaller more targeted areas Foreign travel soon Cases, 30,000 + Now Everyone will be exposed Will the medical system will be overwhelmed? National Health Commission All localities, focus on improving the vaccination rate of people aged 60-79, accelerating the vaccination rate of people aged 80 and above, and making special arrangements Prof Ivan Hung, Hong Kong University The main way for China to exit Covid with the least damage is via vaccination and three doses of vaccination is a must Hopefully before Chinese New Year (January 22) Rabbit Sinopharm Strategic Advisory Group of Experts on Immunization (SAGE) https://www.who.int/news-room/feature-stories/detail/the-sinopharm-covid-19-vaccine-what-you-need-to-know The vaccine is safe and effective for all individuals aged 18 and above. Individuals may choose to delay vaccination for 3 months following the infection. An inactivated vaccine with adjuvant (that is routinely used in many other vaccines) with a documented good safety profile, including in pregnant women. Symptomatic SARS-CoV-2 infection and efficacy against hospitalization 79% Does it prevent infection and transmission? No substantive data Does it work against new variants of SARS- CoV-2 virus? SAGE currently recommends using this vaccine Not yet been evaluated in the context of circulation of widespread variants of concern. How does this vaccine compare to other vaccines already in use? We cannot compare the vaccines head-to-head, (different approaches taken in designing the respective studies) but overall, all of the vaccines that have achieved WHO Emergency Use Listing, are highly effective in preventing severe disease and hospitalization due to COVID-19. Comparison with Western vaccines Pfizer original paper https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 https://www.nejm.org/doi/suppl/10.1056/NEJMoa2034577/suppl_file/nejmoa2034577_appendix.pdf BNT162b2 was 95% effective in preventing Covid-19 Later analysis from Efficacy and effectiveness of covid-19 vaccine - absolute vs. relative risk reduction https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115787/ AAR, Pfizer, during the trial period, 0.84% AAR https://patient.info/news-and-features/calculating-absolute-risk-and-relative-risk Absolute risk of a disease is your risk of developing the disease over a time period. Five to six-months update, AAR BNT162b2 3.7% mRNA1273 (Moderna-NIH) 4.9% Learn more about your ad choices. Visit megaphone.fm/adchoices
Advice is not based on clinical trial data A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19 https://ctv.veeva.com/study/a-study-of-mrna-1283222-injection-compared-with-mrna-1273222-injection-in-participants-12-years-o Key Inclusion Criteria: For female participants of childbearing potential: negative pregnancy test, adequate contraception or has abstained from all activities that could result in pregnancy for at least 28 days prior to the first injection, and agreement to continue adequate contraception or abstinence through 90 days following the vaccine administration. In other words Pregnant or potentially pregnant women are excluded Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 This report does not address the prevention of Covid-19 in other populations, such as younger adolescents, children, and pregnant women. https://www.nhs.uk/pregnancy/keeping-well/pregnancy-and-covid-19/ It's strongly recommended that you get vaccinated against COVID-19 to protect you and your baby. https://www.rcog.org.uk/guidance/coronavirus-covid-19-pregnancy-and-women-s-health/vaccination/covid-19-vaccines-pregnancy-and-breastfeeding-faqs/ (updated on 20 October 2023) COVID-19 vaccines are strongly recommended in pregnancy. Vaccination is the best way to protect against the known risks of COVID-19 in pregnancy for both women and babies https://vaccineknowledge.ox.ac.uk/covid19-vaccines-in-pregnancy#Are-COVID-19-vaccines-recommended-for-pregnant-people COVID-19 vaccines are recommended during pregnancy due to an increased risk of serious illness and complications from COVID-19 in pregnant people, https://www.rcog.org.uk/media/0qune0d3/covid-19-infection-in-pregnancy-v161-final.pdf Vaccination in pregnancy against COVID-19 is strongly recommended 2025 https://www.gov.uk/government/publications/covid-19-vaccination-in-2025-and-spring-2026-jcvi-advice/jcvi-statement-on-covid-19-vaccination-in-2025-and-spring-2026 Pregnancy, neonates and young infants Recent data indicates that the risk of hospitalisation and/or mortality in pregnant individuals has significantly reduced in the Omicron period. Notably, there were no deaths in people who were pregnant in the last 18 months …. JCVI advised that it was highly unlikely that vaccination in pregnancy would be cost-effective. Exclusion of pregnant and lactating women from COVID-19 vaccine trials: a missed opportunity https://pmc.ncbi.nlm.nih.gov/articles/PMC7989536/?utm_source=chatgpt.com The exclusion of pregnant and lactating women from COVID-19 vaccine trials reflects a historic pattern of ‘protection by exclusion’, representing an instance in which the estimated effect of a therapy on mother and child will rely on anecdotal and delayed reports from healthcare settings rather than the monitored setting of a clinical trial. This exclusion is not justified. Learn more about your ad choices. Visit megaphone.fm/adchoices
With Professor Robert Clancy. This is part 1, still editing the next parts.... Link to but the book, https://covidthroughoureyes.com.au/products/covid-through-our-eyes-an-australian-story-of-mistakes-mistreatment-and-misinformation First part of this excellent talk with Professor Robert Clancy, doctor, immunologist, consultant physician, professor of pathology and professor of medicine, highly published medical researcher, author, teacher, doctor of science, doctor of philosophy, holder of the Australia Medal. Letters from Australia is Alison Bevege's Substack, https://lettersfromaustralia.substack.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices
Covid toe, caused by the immune response to the virus, not the virus itself https://covidskinsigns.com https://onlinelibrary.wiley.com/doi/full/10.1111/bjd.20707 Objectives To study skin and blood endothelial and immune system activation In chilblain-like lesions (CLL), CLL in comparison with healthy controls and seasonal chilblains (SC) (cold-induced sporadic chilblains occurring during 2015 and 2019) Methods Observational study Saint-Louis Hospital, Paris, France N = 50 Cytokine assays Assessment of interferon-stimulated gene expression in whole blood Soluble markers of endothelial activation and/or angiogenesis Histological examinations Lateral flow spike assay Circulating endothelial cell counting Statistical analysis Results Histological patterns were similar in CLL and SC groups Transcriptomic signatures overlapped in both the CLL and SC groups Type I interferon Cytotoxic–natural killer gene signature CLL were characterized by higher IgA tissue deposition More complement and angiogenesis factors in CLL compared with SC Autoimmune vasculitis Confirmed endothelial dysfunction in CLL Microangiopathy leading to clinical chilblains Disrupt the thrombo-protective state of endothelial cells Likely contributing to microvascular thrombosis Systemic endothelial activation? The PT ratio and aPTT were normal in all patients Only three patients (6%) had a moderate increase in D-dimer levels Conclusions Inflammation in the skin in CLL Associated with endothelial alteration Immune infiltration of cytotoxic and type I IFN-leading to clinical manifestations https://www.bbc.co.uk/news/health-58801462 UK podiatrist Dr Ivan Bristow like the regular chilblains typically seen during cold spells and in people who have problems with circulation - the lesions usually go away on their own. But some may need treatment with creams and other drugs. The confirmation of the cause will help to develop new treatments to manage it more effectively Dr Veronique Bataille, consultant dermatologist, British Skin Foundation Covid toe was seen very frequently during the early phase of the pandemic, but has been less common in the current Delta variant wave. That might be down to more people being vaccinated or having some protection against Covid from past infections. Presentations after vaccination are much rarer Delayed presentation my mean link is missed Free download my two comprehensive but free educational text books (over 50,000 downloads so far) or make a donation to the campbellteaching project using this link: http://159.69.48.3 Learn more about your ad choices. Visit megaphone.fm/adchoices
Burden and characteristics of COVID-19 in the United States during 2020 Columbia University and NIH, Director Francis S. Collins, Nature https://pubmed.ncbi.nlm.nih.gov/34438440/#affiliation-3 United States, 2020, highest numbers of reported cases and deaths In the light of later antibody studies March 11.3% December, 24.5% Population susceptibility at year's end was 69.0% So, 31% of population had been exposed (100 million people) Prevalence rates rose above 0.8% by end of 2020 As high as 2.4% in some major metropolitan areas Infection fatality rate fell to 0.3% by end of 2020 https://www.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-state-level-data-report/ As of September 2 5,049,465 children have tested positive 252,000 cases were added the past week Largest number of child cases in a week ever Since the pandemic began, children, 15.1% of total cumulated cases Week ending September 2nd, 26.8% of reported weekly COVID-19 cases 2,400 children were hospitalized nationwide (highest in pandemic) Hospitalizations (24 states and NYC reported) Children ranged from 1.6%-4.1% of total cumulated hospitalizations 0.1%-1.9% of all their child COVID-19 cases resulted in hospitalization Mortality (45 states) Children were 0.00%-0.27% of all COVID-19 deaths (7 states reported zero child deaths) 0.00%-0.03% of all child COVID-19 cases resulted in death Vaccination in children Half of children ages 12 to 15 have received at least one vaccine dose 58 percent for 16- and 17-year-olds Anthony Fauci, National Institute of Allergy and Infectious Diseases We’ve got to get the school system masked, in addition to surrounding the children with vaccinated people That’s the solution Los Angeles mandates today Soon mandate vaccination for school attendance 600,000 would have to get their first shot by Oct. 3 Second shot by the end of October (LA counts since last month) Direct link to vote, https://www.youtube.com/c/Campbellteaching/community Pascal Soriot, AstraZeneca chief executive on Booster doses https://www.telegraph.co.uk/business/2021/09/07/covid-booster-jab-campaign-may-not-needed-says-astra-boss/ UK is still "a few weeks away" from being able to decide Moving too quickly to boost across the entire adult population will deprive us of these insights, leaving this important decision to rest on limited data NHS resource implications Nadhim Zahawi NHS is ‘ready to go’ Philip Dormitzer, Pfizer’s chief scientific officer Encouraged booster shots Dismissed criticism that his company should have produced a more potent vaccine Professor Sarah Gilbert https://inews.co.uk/news/politics/creator-oxford-vaccine-sarah-gilbert-warns-vulnerable-will-have-shield-covid-19-cases-rise-1096315 UK, 3.8 million people classed as clinically extremely vulnerable In people who have been vaccinated and have had the two doses, they will be well protected against disease that is severe enough to put them in hospital and against death And there are unfortunately some people with particular health conditions that mean they just don’t respond to a vaccine and they are going to have to make sure that they are protected, probably by shielding again, if there is a lot of spread of the virus https://www.gov.uk/government/publications/guidance-on-shielding-and-protecting-extremely-vulnerable-persons-from-covid-19/guidance-on-shielding-and-protecting-extremely-vulnerable-persons-from-covid-19 we are advising clinically extremely vulnerable people, as a minimum, to follow the same guidance as everyone else you may wish to think particularly carefully about additional precautions you might wish to continue to take Sweden Removing all remaining restrictions by the end of this month Vietnam Health Ministry, offering Pfizer-BioNTech as a second-dose after Moderna (l Learn more about your ad choices. Visit megaphone.fm/adchoices
Less people going to hospital with Omicron infection compared to Delta infection. Apologies, I had a few technical problems with todays video Zoe update: Wednesday 22 December 2021 https://www.youtube.com/watch?v=CIGC310hPoI https://covid.joinzoe.com/post/everything-we-know-so-far-about-omicron https://joinzoe.com/learn/category/covid https://joinzoe.com/learn/new-omicron-variant 144,284 new daily symptomatic cases of COVID in the UK In people who have had at least 2 vaccine doses 56,346 new daily symptomatic cases in the UK 70% + cases in England are now Omicron The UK R value, 1.2 R value in London is 1.5. From 17,000 omicron cases Runny nose Headache Fatigue (either mild or severe) Sneezing Sore throat (NHS test and trace is not telling users of their Omicron status anymore) Report 50 - Hospitalisation risk for Omicron cases in England https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-50-severity-omicron/ https://www.theguardian.com/world/2021/dec/22/risk-of-hospital-stay-40-lower-with-omicron-than-delta-uk-data-suggests Differences in the risk of hospitalisation between Omicron and Delta 1st to 14th December inclusive Analysed data from all PCR-confirmed SARS-CoV-2 cases in England Cases S-gene Target Failure (SGTF) and genetic data Omicron, n = 56,000 Delta, n = 269,000 Reduction in the risk of hospitalisation for Omicron relative to Delta infections Endpoint, any attendance at hospital 20-25% reduced risk Endpoint, hospitalisation lasting 1 day or longer 40-45% reduced risk These reductions must be balanced against the larger risk of infection with Omicron, due to the reduction in protection provided by both vaccination and natural infection. Intrinsic differences in severity between Omicron and Delta Omicron may result in slightly less severe disease From the few neither previously infected nor vaccinated, risk of hospitalisation, 11% lower for Omicron versus Delta Level of protection from previous infection Reduces the risk of any hospitalisation by 50% Reduces the risk of a hospital stay of 1+ days by 61% Risk of symptomatic infection with omicron More protection after PF/MD than AZ Hospitalisation risk by vaccination state AstraZenca (AZ) (doses 1 and 2) Omicron hazard ratios are lower than for Delta Pfizer or Moderna (PF/MD) (doses 1 and 2) Omicron hazard ratios are similar to those seen for Delta Conclusions, after at least 2 vaccine doses Protection against omicron infection has been largely lost Remain substantially protected against hospitalisation Does not substantially change Sage modelling Pointing to 3,000 daily hospitalisations in England at the peak next month Omicron cases in Scotland, Eave II study (Early Pandemic Evaluation and Enhanced Surveillance of COVID-19) https://www.sciencemediacentre.org/data-from-scotland-on-omicron-severity-from-the-eave-ii-study/ https://www.ed.ac.uk/usher/eave-ii/key-outputs/our-publications/severity-of-omicron-variant-of-concern-and-vaccine https://www.research.ed.ac.uk/en/publications/severity-of-omicron-variant-of-concern-and-vaccine-effectiveness- Hospital data from 23 November to 19 December Risk of hospitalisation, 70% lower with Omicron than Delta. 15 hospitalisations with Omicron Opposed to the 47 admissions from delta (Expected given the characteristics of those infected) First case of Omicron confirmed by viral sequencing was recorded in Scotland on November 23, 2021 By December 19, 2021, there were 23,840 S gene negative cases. These S gene negative cases were predominantly in the age group 20-39 (11,732; 49.2%). Reinfections, more than 10 times more likely with omicron Omicron positive cases that were reinfections, 7.6% Delta cases that were reinfections, 0.7% The third/booster vaccine dose was associated with a 57% reduction in the risk of symptomatic Learn more about your ad choices. Visit megaphone.fm/adchoices
Two different manufacturing processes. Pfizer covid vaccines for the clinical trials were mostly produced using manufacturing ‘process 1’ whereas the vaccines used for population vaccination were produced using a different ‘process 2’ Interview with Josh Guetzkow PhD Here is the BMJ link: https://www.bmj.com/content/378/bmj.o1731/rr-2 Josh's handle on X.com is @joshg99 and here is a link to a thread I did on P1 vs. P2: https://x.com/joshg99/status/1658421192326365185 Here is a link to my blog: https://researchrebel.substack.com/ Here are links to my posts on the Pfizer clinical trial https://researchrebel.substack.com/p/comirnaty-or-comirnaughty https://researchrebel.substack.com/p/how-long-did-the-pfizer-covid-vaccine https://researchrebel.substack.com/p/the-pfizer-vaccine-trial-was-not https://www.bmj.com/content/378/bmj.o1731/rr-2 https://www.nejm.org/doi/suppl/10.1056/NEJMoa2034577/suppl_file/nejmoa2034577_protocol.pdf https://twitter.com/joshg99/status/1658421192326365185 https://phmpt.org/wp-content/uploads/2023/04/125742_S1_M5_5351_c4591001-interim-mth6-report-body.pdf Learn more about your ad choices. Visit megaphone.fm/adchoices
Free download for books and posters, https://drjohncampbell.co.uk/ Hard new copy of the Physiology notes if you live in the UK, https://www.ebay.co.uk/p/86647350 Learn more about your ad choices. Visit megaphone.fm/adchoices
World, now up to 226 confirmed cases in 20 countries Moderna, a material drop in efficacy Pfizer applied to FDA to boost 16 and 17 year olds Pfizer's chief scientific officer, Mikael Dolsten https://www.statnews.com/2021/11/30/pfizer-research-head-envisions-a-sprint-to-develop-omicron-vaccine-if-its-needed/ Enough experimental vaccine to begin a clinical trial within about two months Very high commercial scale, by early March cautiously optimistic, especially for the boosted Pathogenicity https://www.dw.com/en/covid-how-dangerous-is-the-omicron-variant/a-59977618 Preliminary data suggests that there are increasing rates of hospitalization in South Africa, but this may be due to increasing overall numbers of people becoming infected, rather than a result of a specific infection with omicron Professor Salim Abdool Karim, South Africa The vaccine should hold well in terms of preventing hospitalizations The European Union 44 confirmed cases in EU countries https://www.telegraph.co.uk/world-news/2021/12/01/eu-must-consider-mandatory-vaccination-says-ursula-von-der-leyen/ Dr. Ursula von der Leyen, European Commission’s President Must consider mandatory vaccination highly contagious omicron variant 150 million not vaccinated This is an enormous health cost coming along 77 % of adults 66% of whole population Greece and Austria already mandating Netherlands 13 cases US Sewage surveillance FDA Narrow vote (14 to 10) approve Merck molnupiravir Only high-risk patients Not in pregnancy UK 22 cases https://www.telegraph.co.uk/politics/2021/11/30/new-covid-restrictions-last-march-next-year/ New self-isolation rules now law 10 days after contact with omicron Even if fully vaccinated Fine up to £10,000 Until March 24 ? new pingdemic Scientific advisory group for emergencies, leak 30 scientists, Patrick Vallance, Chris Whitty https://www.telegraph.co.uk/global-health/science-and-disease/covid-news-cases-deaths-booster-jab-coronavirus-omicron/ Stringent response measures may be needed for omicron highly likely that omicron, after infection or vaccination to some extent there will be immune escape Expects booster jabs to provide protection for now Future remains highly uncertain potentially very significant wave of infections Covid symptom tracker data https://covid.joinzoe.com/data#levels-over-time WHO advice for international traffic in relation to the SARS-CoV-2 Omicron variant (B.1.1.529) https://www.who.int/news-room/articles-detail/who-advice-for-international-traffic-in-relation-to-the-sars-cov-2-omicron-variant Preliminary evidence suggests an increased risk of reinfection with this variant as compared to other VOCs Current SARS-CoV-2 polymerase chain reaction (PCR) diagnostics continue to be effective Blanket travel bans will not prevent the international spread People not fully vaccinated, sick or at increased risk, should be advised to postpone travel to areas with community transmission Learn more about your ad choices. Visit megaphone.fm/adchoices
Significant Increase in Excess Deaths after Repeated COVID-19 Vaccination in Japan https://pubmed.ncbi.nlm.nih.gov/40416011/ Although Japan recorded the world's highest rate of COVID-19 messenger ribonucleic acid (mRNA) vaccination doses per capita, (3.3 doses, 0 -8) COVID-19 cases and deaths exploded after the emergence of the Omicron variant, (despite more than 80% of the population having been fully vaccinated) followed by a significant increase in excess deaths in 2022 and 2023. Although several hypotheses have been proposed to explain these phenomena, the truth remains to be established because sufficient studies and data disclosures have not been conducted to adequately investigate the possible contribution of mRNA vaccines. The causes of the excess deaths from not only COVID-19 but also other factors after repeated mRNA vaccinations must be elucidated, given this could provide valuable information to help combat future infectious disease outbreaks. Japan, 2022 and 2023, excess deaths per million More than 1,400 (three times higher than that in the United States) COVID-19 deaths in Japan accounted for only 10% of these excess deaths Another hypothesized cause of the excess deaths is various adverse reactions to COVID-19 vaccinations. As of November 18, 2024, Japan After COVID-19 vaccination Government has provided payouts for 8, 432 injuries Payouts after 903 deaths Numbers that are still increasing, already greatly exceed the numbers of injuries and deaths, for which payments were made, after all other vaccinations in the last 47 years. Many injuries and deaths in the young population E.g. fatal case, 14-year-old girl (vaccinate to protect granny) This policy contradicts an early study (August 2021) showing vaccination did not reduce the viral load of infected individuals Adverse reactions reported Myocarditis, pericarditis, blood clotting, and autoimmune diseases linked to lipid nanoparticles (LNPs) and excessive production of spike proteins generated by the mRNA. Deaths from cancers related to estrogen receptors, such as leukemia, breast, pancreatic, lip/oral/pharyngeal, ovarian, and uterine cancers, have also increased since the population-wide administration of mRNA vaccinations Spike protein of SARS-CoV-2 is known to bind to estrogen receptors, located in the nucleus, and includes a nuclear localization signal, which makes it more likely to be conveyed to the nucleus. Another hypothesis involves chronic infection caused by immunosuppression after repeated vaccination. Indeed, recent studies have reported an increase in spike-specific (more immunoglobulin G4, more regulatory T cells) Wastewater monitoring data support this claim. Robert Redfield “The benefit to the 30-year-old firefighter, I don’t see the benefit.” “There’s prolonged production or impact or negative consequence from spike protein in some people that get the mRNA vaccine.” The concerns related to the mRNA-LNP formulation evidently need to be taken seriously. Thus, it is imperative to elucidate the effects of population-wide COVID-19 vaccination. Japanese health authorities have been hesitant to provide data It was revealed that the vaccinated were as susceptible as or even more susceptible to COVID-19 infection than were the unvaccinated Learn more about your ad choices. Visit megaphone.fm/adchoices
Which is way higher than the UK figure CDC, Long covid Latest UK figures https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19latestinsights/infections 2.8% of the population, self-reported Of those, 73% symptoms at least 12 weeks 44% symptoms at least one year Post–COVID Conditions Among Adult COVID-19 Survivors Aged 18–64 and ≥65 Years — United States, March 2020–November 2021 https://www.cdc.gov/mmwr/volumes/71/wr/mm7121e1.htm?s_cid=mm7121e1_e&ACSTrackingID=USCDC_921-DM82414&ACSTrackingLabel=MMWR%20Early%20Release%20-%20Vol.%2071%2C%20May%2024%2C%202022&deliveryName=USCDC_921-DM82414#contribAff Previously infected with SARS-CoV-2, reported persistent symptoms ≥4 weeks after acute COVID-19 March 2020–November 2021 United States, aged ≥18 Incidence of 26 conditions often / previously attributable to post-COVID Among all patients aged ≥18 years 38% of case-patients experienced an incident condition 16% of controls 18–64 years 35.4% of case-patients experienced at least one incident condition 14.6% of controls experienced at least one incident condition Aged ≥65 years 45.4% of case-patients experienced at least one incident condition 18.5% of controls experienced at least one incident condition. Survivors aged 18–64 One in 5 Survivors aged ≥65 One in 4 experiencing an incident condition that might be attributable to previous COVID-19 Conditions affected multiple systems cardiovascular, pulmonary, hematologic, renal, endocrine, gastrointestinal, musculoskeletal, neurologic, and psychiatric signs and symptoms Highest risk ratios (RRs) Acute pulmonary embolism 18 to 64, RR = 2.1 ≥65, RR = 2.1 RR = 2.1 and 2.2 among persons aged 18–64 and ≥65 years, respectively) and Respiratory signs and symptoms RR = 2.1 in both age groups Critical to reducing the incidence and impact of post-COVID Implementation of COVID-19 prevention strategies Routine assessment for post-COVID conditions is critical to reducing the incidence and impact of post-COVID The research study A retrospective matched cohort design March 2020–November 2021 63.4 million unique adult records 110 data contributors in the 50 states Case-patients, 353,164 Control patients, 1,640,776 Case-patients or control patients with a previous history of one of the included conditions were excluded No significant difference Cerebrovascular disease Mental health conditions Substance-related disorders Differences by age group were noted RR for cardiac dysrhythmia 18 to 64, RR = 1.7 ≥65, RR = 1.5 Musculoskeletal pain 18–64, RR = 1.6 ≥65, RR = 1.4 RRs for 10 incident conditions, significantly higher among those aged ≥65 Renal failure, thromboembolic events, cerebrovascular disease, type 2 diabetes, muscle disorders, neurologic conditions, and mental health conditions (including mood disorders, anxiety, other mental conditions, and substance-related disorders Limitations Patients infected with recent variants Acute COVID-19 infection might be biased toward a population that is seeking care COVID-19 vaccination status was not considered in this analysis Learn more about your ad choices. Visit megaphone.fm/adchoices
This excellent scientific analysis of recent events continues in interview two of this series. Follow Dr. Craig on SubStack, https://drclarecraig.substack.com COVID, the untold story. So much more makes sense after this book and my first illuminating discussion with Dr. Craig. Get your copy in the UK here: https://www.amazon.co.uk/Expired-untold-Dr-Clare-Craig/dp/1739344707 For friends in the US get your copy here, https://www.amazon.com/Expired-untold-Dr-Clare-Craig/dp/1739344707 Have you ever felt the covid story did not entirely add up? Expired contains multiple eye-opening revelations about covid with compelling evidence that provides a coherent, sober and clear explanation that better fits the data we have so far. Meticulous research by pathologist Dr Clare Craig sheds light on the largely overlooked evidence of airborne virus transmission, examining twelve related beliefs on spread, lockdowns, asymptomatic infections, and masks. In addition, Expired champions the importance of Western ethical principles, damaged by pandemic actions and calls for their restoration. The covid debate has proved incredibly polarising. One side believed every intervention was saving lives, while the other emphasised the harms caused. Biased modelling based on a worst-case scenario led to fearful assumptions presented as fact. By dint of sheer repetition these ‘facts’ became unquestionable. Those scientists who dared to question were proclaimed dangerous. Welcome to Cloud-Covid-Land. Let’s bring back nuance. It’s time to return to reality." Learn more about your ad choices. Visit megaphone.fm/adchoices
Omicron in the US is rip roaring away SA data https://www.nicd.ac.za/diseases-a-z-index/disease-index-covid-19/surveillance-reports/daily-hospital-surveillance-datcov-report/ Omicron variant, Houston Methodist patients https://www.houstonpublicmedia.org/articles/news/health-science/2021/12/17/415844/omicron-variant-is-now-responsible-for-nearly-half-of-houston-methodists-covid-19-cases/ https://www.houstonpublicmedia.org/articles/news/health-science/2021/12/15/415577/houston-hospitals-see-a-covid-19-uptick-as-omicron-and-delta-continue-to-spread/ Omicron variant, doubling every two to three days At least 45% of Methodist’s COVID-19 patients were omicron as of Friday Wednesday, 32% COVID-19 tests on symptomatic patients Saturday, (4 days before) 13% Half of the hospital’s omicron patients have been vaccinated with either two or three doses Four times as many positive COVID-19 test results since last week Fueled by the continued spread of the omicron variant Dr. Marc Boom, Methodist president and CEO If this spreads so rapidly that there are massive numbers of infected people, even if on average they’re very mild, if that hits the vulnerable in our population and they end up hospitalized, that can still be an incredibly challenging time S. Wesley Long, medical director of diagnostic microbiology Very likely reach 100% of all COVID-19 cases within the hospital by January That would be a faster sweep than even the delta variant, which took about a three-month span to sweep prior variants and achieve 100%, It is also possible that delta remains in some equilibrium with omicron over time US Cases https://covid.cdc.gov/covid-data-tracker/#trends_dailycases Hospitalizations https://covid.cdc.gov/covid-data-tracker/#hospitalizations Rip roaring away Could bring the highest level of cases yet https://www.washingtonpost.com/nation/2021/12/20/covid-omicron-variant-live-updates/ New York City Mayor Bill de Blasio we are seeing a very substantial rise in the number of cases in a way we haven’t seen previously New York adults had at least one dose, 94% People with 2 doses, 70% (10% above national rate) Dr. Anthony Fauci https://www.nbcnews.com/news/us-news/fauci-warns-omicron-variant-raging-world-rcna9293 raging around the world Omicron variant is really something to be reckoned with Our hospitals, if things look like they're looking now, in the next week or two are going to be very stressed because, again, we have so many people in this country who are eligible to be vaccinated who have not yet been vaccinated The hospitalization to case ratio appears to be smaller than delta We are going to see breakthrough infections, there's no doubt about that The difference between a vaccinated and boosted person who has an infection and someone who has an infection who's never been vaccinated, there's a major difference with regard to the risk of severity President Biden, winter plan tomorrow Lots of flights Broadway cancelled Sports events cancelled Education going remote UK surge Omicron Cases, + 12,133 + 8,044 = 45,145 https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1042543/20211220_OS_Daily_Omicron_Overview.pdf https://covid.joinzoe.com/data#levels-over-time https://coronavirus.data.gov.uk London hospital admissions Professor Niels Hoiby Denmark Total vaccinated with mRNA vaccine = 4,304,710 Total myocarditis + pericarditis = 129 (0.003%) One case in 33,369 Norway Total vaccinated with mRNA vaccine = 3.765.354 Total myocarditis + pericarditis = 274 (0.0073%) One case in 13,743 2.4 times more cases in Norway Learn more about your ad choices. Visit megaphone.fm/adchoices
This is a great organisation I have been involved with for 12 years now. I fully attest to the veracity and dedication of all the staff I have met. The founder is Anne Chege, who my brother and I know well. Anne worked with Barclays Bank for 28 years, looking after orphans and abandoned children within her own home. On retirement she opened this centre and has dedicated her life to the work. To contribute to this work, https://www.buymeacoffee.com/newhopechi3 Learn more about your ad choices. Visit megaphone.fm/adchoices
‘I should decide if my vulnerable adult son has a Covid vaccine – not a judge’ Sarah’s instinct to protect Tom, a 24-year-old with complex medical conditions, could be overridden by one of Britain’s most powerful courts https://www.telegraph.co.uk/health-fitness/parenting/children/covid-vaccine-health-risks-court-heart-vulnerable-son/ ‘They should be proving to us that it’s safe, not me trying to prove it isn’t’ ‘All I’ve ever wanted to be is a great mother and to protect my son’ Mum Sarah and son Tom (23 years / 18 months LD) Congenital heart condition Chromosomal condition, Partial Trisomy 13 She dared to question whether the Covid-19 vaccine was safe for her vulnerable son Nearly three years, Court of Protection Whether the greater good – for Tom and society – will be served by him being injected (despite complex medical conditions) Sarah Claims state being “heavy-handed”, insisting it knows better than a mother. Tom had all his childhood vaccines. Her fear about the vaccine mRNA suitable in multiple pathology? Dentists, needs antibiotics 2021 Tom contracted covid twice, recovered quickly. Sarah repeatedly asking medical professionals “I went to talk to my GP about my concerns,” “I explained that I was worried there was a possibility the vaccine could cause myocarditis or pericarditis” “At the end of our chat when I said I was concerned about Tom having the vaccine, the doctor simply said he needed to tick some boxes for the relevant “agencies”. I didn’t think any more of it.” A few days later Social worker unexpected visit. Then, a physiotherapist Both questioned about why Tom had not yet had the vaccine. “I felt they should be proving to us that it’s safe, not me trying to prove it is not safe.” April 2021 Court summons, signalling the beginning of a protracted and ongoing legal tussle with the state. Judge Burrows legal “impasse” “on the advice given to clinicians by effectively the UK Government” Sarah “the risks posed by the vaccine were unclear and maybe significant.” Judge Burrows Tom was in an at-risk group, “the evidence is that vaccines do give protection against serious illness and death.” Whether Tom “may have made an altruistic decision to receive the vaccine to protect the community at large” “In other words: might Tom have behaved like a responsible citizen and considered the effect of his decision on other people had he made the decision for himself.” “it is in Tom’s best interest to receive the vaccine” Court battle is still ongoing. Sarah Crowdfunding site – “Forced Vaccinations On Our Loved Ones” So far, those who believe mother knows best have raised more than £35,000. Sarah has spent £25,000 of her own life savings. Professor World expert in Trisomy 13, told the court the vaccine could pose a threat to Tom. If the court ultimately orders that Tom should be vaccinated, any attempt by his mother to prevent that happening could culminate in her being jailed or assets being seized. Sarah “‘He is currently a fit and well young man with no comorbidities and he takes no medications. “The injection could potentially injure or kill him. If he is given the vaccine, one of my greatest fears is that he cannot speak and express how he is feeling should he have an adverse reaction. “I have dedicated my whole life to overseeing his health and worked tirelessly with the medical community to develop intricate and personalised care regimes,” “It’s my care which has contributed to Tom living until he is 24, despite Trisomy 13 often resulting in a limited lifespan. “For the judge to believe that Tom would take it for the sake of others – the so-called altruistic view – denies the possibility that there is any risk at all to Tom. “I would think he’d protect his own life by not taking it.” “All I have ever wanted to be is a great mother and to protect my son Learn more about your ad choices. Visit megaphone.fm/adchoices