AJT Highlights

American Journal of Transplantation

Host Roslyn Mannon, MD, discusses the latest issues of the American Journal of Transplantation, summarizing Editors’ Picks by highlighting the key messages, broader impact, and take-home points of each article. The views are her own and do not necessarily reflect those of the journal or the societies that support it.

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#105
September 1 · 43 min
AJT September 2026 Editors’ Picks
AJT September 2026 Editors’ Picks Description: Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the September issue of the American Journal of Transplantation. [2:55] A remote intervention to improve medication nonadherence guided by a marker of risk derived from the electronic health records of adolescent transplant recipients [15:02] On the relative relevance of donor-derived cell-free DNA and urinary chemokines as noninvasive biomarkers for the diagnosis of kidney allograft rejection [28:49] Pre- and post-kidney transplant gnathostomiasis: Clinical manifestations, treatment, and outcomes [34:50] Metabolomic atlas of ischemia-reperfusion injury in human lung transplants: Mitochondrial stress and primary graft dysfunction
#104
August 1 · 45 min
AJT August 2026 Editors’ Picks
Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Alessia Giarraputo to discuss the key articles of the August issue of the American Journal of Transplantation. Alessia Giarraputo is a postdoc research fellow at Mass General Hospital and Harvard Medical School [3:38] Donor-reactive clonotypes are overrepresented in the urinary T cell repertoire during kidney transplant rejection and show distinct dynamics in the circulation [13:57] Organ-specific differences in the epidemiology of cytomegalovirus infections in high-risk (cytomegalovirus donor seropositive, recipient seronegative) solid organ transplant recipients with prolonged follow-up: A 10-year experience [22:17] Immune checkpoint inhibitors after liver transplantation: The role of immunosuppressive management [28:34] Expert consensus on the use of immune checkpoint inhibitors in the liver transplant setting: Guidance from the Liver Transplant Committee of the Italian Association for the Study of the Liver (AISF) [33:50] Outcomes of kidney transplants from pediatric donors with acute kidney injury
#103
July 1 · 44 min
AJT July 2026 Editors’ Picks
Description: Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the July issue of the American Journal of Transplantation. [3:52] Simultaneous quantification of native human and transgenic porcine liver function in a decedent model of extracorporeal cross-circulation [12:11] Pathologic evaluation of pig kidney and heart xenografts: 2024 recommendations from the Banff Xenotransplantation Pathology Working Group [13:36] The use of a centralized normothermic preservation and assessment center to rescue kidneys declined after standard allocation [25:57] Machine perfusion modulates cold-preservation injury in kidney transplantation: IDEAL stage 4 United States population cohort study [37:05] Impaired thymic function is independently associated with an increased risk of posttransplant infections in kidney recipients
#102
June 15 · 25 min
AJT June 2026 Editors’ Picks
Description: Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the June issue of the American Journal of Transplantation. [3:32] MHC Matchmaker: An in silico based algorithm to analyze cross-species NHP, pig, and human MHC compatibility on the amino acid level [11:50] Wisdom of the Crowd: Ensuring the justness and validity of group decision-making in solid organ transplant [16:39] Inhibition of cytomegalovirus reactivation by ex vivo treatment of human kidneys with the SYN002 immunotoxin [22:20] There is nothing equitable about a wasted organ; eliminating out-of-sequence allocation for 30 days decreases utilization of hard-to-place kidneys
#101
May 1 · 39 min
AJT May 2026 Editors’ Picks
Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Somaya Zahran to discuss the key articles of the May issue of the American Journal of Transplantation. Somaya Zahran is a transplant nephrology fellow at the Mayo Clinic in Rochester. [03:06] Sensitization in organ transplantation: Assessment of Risk (STAR) 2025 meeting group report [08:55] The Banff 2024 Kidney Meeting Report: Rejection as a spectrum of phenotypes and focus on differential diagnostic reasoning [22:17] Normothermic versus hypothermic machine perfusion in kidney transplantation: A randomized controlled trial [27:36] Gene-edited pig cardiac xenotransplantation as a bridge to allotransplantation in infants: Progress in a pig-to-baboon model
#100
April 1 · 50 min
AJT April 2026 Editors’ Picks
AJT April 2026 Editors’ Picks Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Cesar Berto to discuss the key articles of the April issue of the American Journal of Transplantation. Dr. Cesar Berto is an Assistant Professor at the University of Alabama, Birmingham, in the Division of Infectious Diseases [03:28] Invasive mold infection in heart transplant recipients: A nationwide multicenter matched case–control study between 2008 and 2022 in France [08:50] Pharmacokinetics, lineage identity, and trafficking of ex vivo expanded polyclonal regulatory T cells in a prospective randomized clinical trial of kidney transplant recipients with allograft inflammation [20:55] Transmembrane protein 16F-chloride intracellular channel 1 interaction mediates recipient dendritic cell cross-decoration after transplantation [31:27] Dual costimulation blockade with the CD154-specific fusion protein dazodalibep and belatacept for prophylaxis of kidney allograft rejection [43:52] Costimulatory blockade and infectious risk in solid organ transplantation
#99
March 12 · 31 min
The History of Transplant
In this specialty podcast, Dr. Justin Barr is joined by Dr. Thomas Schlich and Dr. Susan Lederer to discuss the early history of transplant surgery, with Dr. Schlich focusing on the mostly European efforts inaugurating solid organ transplant between 1880 and 1910 whilst Dr. Lederer concentrates on skin, blood, and corneal transplants in early 20th century America. Justin Barr practices abdominal transplant and advanced hepatobiliary surgery at the Ochsner Clinic Thomas Schlich is the James McGill Professor and Department Chair at McGill University Susan E. Lederer is the Ronald Numbers Professor of History of Medicine and Bioethics at the University of Wisconsin–Madison References: The Origins of Organ Transplantation Flesh and Blood: Organ Transplantation and Blood Transfusion in Twentieth-Century America
#98
March 1 · 51 min
AJT March 2026 Editors’ Picks
Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Justin Barr to discuss the key articles of the March issue of the American Journal of Transplantation. Justin Barr practices abdominal transplant and advanced hepatobiliary surgery at Ochsner Medical Center [03:13] Implementation of a physician assistant-led recovery model for heart transplantation: Clinical outcomes and programmatic benefits at a high-volume center [13:54] A 100-year simulation of the National Kidney Registry’s voucher program [25:32] Risk of deficient mismatch repair colorectal cancer and precursors after kidney transplantation: A nationwide study [35:09] Predictive value of torque teno virus viral load for BK polyomavirus DNAemia depends on BK polyomavirus–specific humoral immunity in kidney transplant recipients [42:50] Suppression of cardiac allograft vasculopathy by a macrophage efferocytosis receptor
#97
February 2 · 54 min
AJT February 2026 Editors’ Picks
Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Juan Pablo Huidobro to discuss the key articles of the February issue of the American Journal of Transplantation. Juan Pablo Huidobro is an Assistant Professor in Nephrology at Pontifical Catholic University of Chile [02:52] Evolving landscape of thrombotic microangiopathy in kidney transplant recipients in the post–C5 inhibitor era [13:22] Erythropoietin prolongs graft survival in mice by counteracting trained immunity [22:06] A new principle to attenuate ischemia reperfusion injury in kidney transplantation [33:14] Sustained allogeneic kidney graft operational tolerance despite discontinued conventional immunosuppression after CD19-CAR-T-cell therapy for relapsed/refractory post-transplantation lymphoproliferative disorder [40:15] Bloodstream Infection Subtypes and Characteristics Comparing Solid Organ Transplant and Non-Transplant Populations
#96
January 1 · 49 min
AJT January 2026 Editors’ Picks
AJT January 2026 Editors’ Picks Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Dr. Al-Faraaz Kassam to discuss the key articles of the January issue of the American Journal of Transplantation. Al-Faraaz Kassam is an Assistant Professor in Transplant Surgery at Johns Hopkins University [03:45] Evaluation of kidney procurement biopsy and machine perfusion on allograft outcomes: A retrospective cohort study of the OPTN database [11:23] Improving the histologic detection of donor-specific antibody-negative antibody-mediated rejection in kidney transplants [23:01] Exosome-primed T cell immunity is facilitated by complement activation [32:26] Landscape of subclinical rejection in a large international cohort of pediatric kidney transplant (kTx) recipients [42:19] Donor Heart Preservation at 10°C After Thoracoabdominal Normothermic Regional Perfusion Lowers Rates of Severe Primary Graft Dysfunction and Improves Recipient Transplant Outcomes
#95
Dec 1, 2025 · 58 min
AJT December 2025 Editors’ Picks
AJT December 2025 Editors’ Picks Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Hannah Bahakel to discuss the key articles of the December issue of the American Journal of Transplantation. Hannah Bahakel is a Clinical Immunodeficiency fellow at Cincinnati Children’s Hospital Medical Center [03:34] Higher vs standard mean arterial pressure target in the immediate postoperative period of liver transplantation to prevent acute kidney injury: A randomized clinical trial (LIVER-PAM) [13:51] Donor-derived cell-free DNA significantly improves rejection yield in kidney transplant biopsies [26:27] Tolerogenic lung allograft microenvironment suppresses pathogenic tissue remodeling following respiratory virus infection in mice [37:11] Therapeutic needs in solid organ transplant recipients: The American Society of Transplantation patient survey [48:19] Impact of kidney function on 200 days of antiviral prophylaxis for cytomegalovirus disease in cytomegalovirus-seronegative recipients of cytomegalovirus-seropositive donor kidneys: Post hoc analysis of a randomized, phase 3 trial of letermovir vs valganciclovir prophylaxis
#94
Nov 1, 2025 · 47 min
AJT November 2025 Editors’ Picks
Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Christie Rampersad to discuss the key articles of the November issue of the American Journal of Transplantation. Christie Rampersad is clinical associate, in the Division of Nephrology at the University of Toronto in the Ajmera Transplant Centre [03:45] The early impacts of an attempt to standardize kidney procurement biopsy practices [13:40] The current state of simultaneous heart-liver transplantation in the United States [20:11] Engaging patients in organ transplant listing meetings: A survey study [37:32] Single-cell transcriptional landscape of liver transplant rejection reveals tissue persistence of clonally expanded, treatment-resistant T cells [45:32] Infectious disease surveillance and management in clinical xenotransplantation: Experience with the first human porcine kidney transplant
#93
Sep 26, 2025 · 46 min
AJT October 2025 Editors’ Picks
AJT October 2025 Editors’ Picks Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Dr. Christina Haugen to discuss the key articles of the October issue of the American Journal of Transplantation. Dr. Christina Haugen is an Assistant Professor of Surgery at the University of Cincinnati. [03:28] Renal resistance trajectories during hypothermic machine perfusion in kidneys donated after circulatory death: Associations with donor characteristics and posttransplant outcomes—An analysis of COMPARE trial data [10:26] Donor-specific mesenchymal stem cell infusion in human and nonhuman primate kidney transplantation [19:21] Potential targeting of urokinase-type plasminogen activator receptor–formyl peptide receptor signaling to prevent recurrence in posttransplant primary podocytopathies [30:20] The relationship between cessation of brain and systemic circulation after withdrawal of life-sustaining measures [36:03] Pretransplant natural antibody levels identify a subset of deceased donor kidney transplant recipients that benefit from infliximab induction
#92
Sep 2, 2025 · 55 min
AJT September 2025 Editors’ Picks
Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the September issue of the American Journal of Transplantation. [03:30] Blunted cardiac reserve as a marker of cirrhotic cardiomyopathy—Cardiac outcomes following liver transplantation and comparison to the existing guidelines [14:18] Back-table intra-arterial administration of C1 esterase inhibitor to deceased donor kidney allografts improves posttransplant allograft function: Results of a randomized double-blind placebo-controlled clinical trial [25:55] Donor-derived cell-free DNA is associated with the degree of immunosuppression in lung transplantation [36:24] A two-threshold algorithm using donor-derived cell-free DNA fraction and quantity to detect acute rejection after heart transplantation [45:00] Cell therapy with human Interleukin 10–producing ILC2s enhances islet function and inhibits allograft rejection
#91
Aug 1, 2025 · 21 min
Kidney transplantation for undocumented immigrants in the United States: challenges and Ethical considerations
In this Specialty Podcast, Dr. Dami Ko is joined by Dr. Katherine Rizzolo, and Dr. Leonela Villegas to discuss kidney transplantation for undocumented immigrants in the United States, particularly the challenges they face and ethical considerations. Dr. Dami Ko is an assistant professor at Northeastern University, specializing in post-transplant care and quality of life. Dr. Katherine Rizzolo is a nephrologist in Boston, MA. Dr. Leonela Villegas is a Pediatric Nephrologist at Hartford, CT References: Long-term impact of immigration status on outcomes in pediatric kidney transplant recipients. Successful pathways to liver transplant for undocumented immigrants. Undocumented immigrants: A glaring inequity in transplant.
#90
Aug 1, 2025 · 42 min
AJT August 2025 Editors’ Picks
Hosts Roz and Alberto are joined by new Editorial Fellow Dr. Sofia Bin to discuss the key articles of the August issue of the American Journal of Transplantation. Dr. Sofia Bin is an assistant professor of medical and surgical sciences at the University of Bologna. [02:46] Gut microbiome alterations precede graft rejection in kidney transplantation patients [10:31] Molecular diagnosis of kidney allograft rejection based on the Banff Human Organ Transplant gene panel: a multicenter international study Editorial: Graft biopsy reimagined: Integrating morphology and molecular maps [22:20] Does a changing donor pool explain the recent rise in the United States kidney nonuse rate? [32:45] A scintigraphic look at the dead donor rule in donation after the circulatory determination of death with the use of normothermic regional perfusion: A single-center interventional trial Editorial: Normothermic regional perfusion in donation after circulatory determination of death—Confirming the absence of brain reperfusion [37:03] Global variation in living donor liver transplantation practices impacts donor and recipient short-term outcomes: initial insights from the International LDLT Registry
#89
Jul 2, 2025 · 47 min
AJT July 2025 Editors’ Picks
Hosts Roz and Alberto discuss the key articles of the July issue of the American Journal of Transplantation. [03:48] Liver transplantation for hepatitis D virus/hepatitis B virus coinfection in Italy: an intention-to-treat analysis of long-term outcomes [13:42] 10 degree C static storage of porcine donation after circulatory death livers improves biliary viability and mitigates ischemia-reperfusion injury [22:20] Fewer medullary pyramids in the living kidney donor are associated with graft failure in the recipient [33:35] Microvascular inflammation in kidney allografts: New directions for patient management MOMOT (Mouse Models in Transplant) articles: Can mouse kidney transplant models inform mechanisms of injury and acceptance in clinical kidney transplantation? Best practices in islet transplantation in mice
#88
Jun 3, 2025 · 42 min
AJT June 2025 Editors’ Picks
Host Roz is joined by new co-host Alberto Sanchez-Fueyo, MD, PhD to discuss the key articles of the June issue of the American Journal of Transplantation. Dr. Sanchez-Fueyo is a Professor of Hepatology, and the Academic Director of the Institute of Liver Studies, King's College, London. [02:51] Recipient toll-like receptor 4 determines the outcome of ischemia-reperfusion injury in steatotic liver transplantation in mice [10:47] Association between everolimus combination therapy and cancer risk after liver transplantation: A nationwide population-based quasi-cohort study [21:35] Balancing equity and human leukocyte antigen matching in deceased-donor kidney allocation with eplet mismatch Editorial: Equitable allocation through human leukocyte antigen eplet matching: A promising strategy with several challenges [32:51] Impact of the lung allocation system score modification by blood type on US lung transplant candidates Editorial: From flawed to fairer: Reducing blood type bias in lung transplant allocation Recommended article: The economic value of a transplant nephrologist: The case for improving compensation models
#87
May 29, 2025 · 31 min
Overcoming Barriers: Revitalizing Pancreas Transplantation in the U.S.
In this specialty podcast, Dr. Alissar El Chediak is joined by Dr. Jon Odorico and Dr. Ron Parsons to discuss the current state of pancreas transplantation, identify barriers and strategies for referral and candidate selection, and discuss solutions to address the decline in procedures. Alissar El Chediak, MD is a transplant nephrologist at UT Southwestern Medical Center. Jon Odorico, MD is a transplant surgeon at the University of Wisconsin. Ron Parsons, MD is a transplant surgeon at the University of Pennsylvania. References: Generating strategies for a national comeback in pancreas transplantation: A Delphi survey and US conference report
#86
May 28, 2025 · 32 min
Bird Flu and Transplant Patients: Emerging Risks and Clinical Insights
In this Specialty Podcast, Dr. Alejandra Mendoza is joined by Dr. Cameron Wolfe, infectious diseases specialist at Duke University, to discuss the growing concern of avian influenza (H5N1) in transplant recipients. Together, they explore the latest epidemiologic developments, potential risks to immunocompromised patients, and key considerations for clinicians managing solid organ and stem cell transplant recipients in the face of this evolving threat. Dr. Alejandra Mendoza is a transplant infectious diseases physician at the University of Utah. Dr. Cameron Wolfe is a professor of medicine in the division of infectious diseases at Duke University. References: Clinician Update on Human Cases of H5N1 and Influenza A Virus Surveillance (COCA Calls)

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